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NanoSIMS-HR & Cryo

The next frontier in nanoanalysis for science & high-tech

The NanoSIMS‑HR is the next generation of the world-acclaimed NanoSIMS 50/50L Secondary Ion Mass Spectrometer series, which has contributed to major advances across a wide range of scientific disciplines and industrial applications, including materials science and semiconductors, geo- and cosmochemistry, plant and soil sciences, environmental microbiology, cell biology, and medical research.
 
With the NanoSIMS‑HR, CAMECA introduces breakthrough innovations that expand the capabilities of this unique ion microprobe, enhance data quality, and help scientists and engineers accelerate research, discovery, and innovation in increasingly demanding environments with higher workloads and tighter deadlines.

Discover NanoSIMS Cryo – Unlock native chemistry at the nanoscale

The NanoSIMS Cryo accessory extends the capabilities of the NanoSIMS-HR by enabling analysis of samples in their native frozen-hydrated state. By preserving structural and chemical integrity throughout cryogenic sample preparation and transfer, NanoSIMS Cryo enables elemental and isotopic imaging under conditions that closely reflect the original state of the specimen.

For life science applications, biological samples can be analyzed without the dilution and redistribution artefacts often associated with conventional resin-embedding workflows. For soft materials research, NanoSIMS Cryo preserves native morphology and composition, enabling the investigation of elemental and isotopic distributions while maintaining structural integrity.

Fully integrated into the cryogenic workflow — from sample preparation and transfer to NanoSIMS-HR analysis — NanoSIMS Cryo combines high spatial resolution, high mass resolution, and high sensitivity under cryogenic conditions. Scientists can investigate complex processes with greater confidence, extending the reach of nanoanalysis into previously inaccessible application domains.
  • Product overview +


    Key improvements and new features of the NanoSIMS-HR include:

    Improved accuracy

    • Unprecedented lateral resolution (30 nm) thanks to new cesium source and redesigned platform equipped with anti-vibration isolation
    • Depth resolution down to 12 nm per decade for depth profiles down to 8 x 8 µm2 area thanks to new electronics facilitating instrument tuning
    • Fluid inclusion analysis with cold stage

    Improved throughput
    • 2.5x faster image acquisition at 100 nm lateral resolution thanks to brighter cesium source with higher current density
    • A variety of larger sample holders can now accomodate more samples of various sizes
    • 10x more precise sample stage enabling faster acquisition of smaller images, and thus 10x faster unattended chained analysis

    Ease of use
    • Automated introduction from storage to analysis chamber
    • Easy and accurate navigation on 3.6 x 4 mm2 optical image to directly target regions of interest
    • New high resolution electronics facilitating peak centering and tuning optimisation
    • Remote operation facilitating large analysis sessions that necessitate multiple sample holders

    Reliability & Uptime
    • Upgraded Rf-Plasma O- source with optimum cooling system
    • Latest Pfeiffer turbomolecular and primary pumps
    • New control electronics including redesigned high voltage power supply

    Key improvements with NanoSIMS Cryo:

    Highest sample fidelity
    • Preserve samples in their native states
    • True subcellular ion distribution & heterogeneity
    • Reveal previously invisible micrometer scale composition of soft materials
       
  • FAQs on NanoSIMS Cryo +


    What sets NanoSIMS Cryo apart from other NanoSIMS configurations?

    NanoSIMS Cryo uniquely combines nanometer‑scale chemical and isotopic imaging with true cryogenic sample handling. Unlike conventional NanoSIMS workflows, it enables the analysis of wet, volatile, soft, or beam‑sensitive samples in their native frozen state, preserving both chemical distribution and structure. This opens access to applications that were previously impossible or strongly compromised by dehydration, embedding, or chemical fixation. 

    How does NanoSIMS Cryo preserve the native state of samples during analysis?

    NanoSIMS Cryo maintains samples at cryogenic temperatures from loading through analysis, using dedicated cryo stages in both the load‑lock and analysis chamber. By keeping samples frozen, it prevents redistribution of mobile species, loss of volatiles, and preparation‑induced artifacts, ensuring that the chemical maps reflect the true in‑situ state of the material or biological system. 

    Why does cryogenic analysis matter for NanoSIMS applications?

    For many applications—biology, soft matter, geochemistry, and emerging industrial use cases—the native state is the signal. Cryogenic analysis allows researchers to study metabolism, ion transport, drug distribution, fluid inclusions, or emulsions as they exist in reality, rather than after heavy sample transformation. This is critical for drawing quantitative, mechanistic, and actionable conclusions. 

    Can NanoSIMS Cryo handle beam‑sensitive or volatile materials?

    Yes. NanoSIMS Cryo is specifically designed for beam‑sensitive, hydrated, or volatile‑rich materials such as biological tissues, cells, emulsions, frozen fluids, and soft polymers. Cryogenic preservation significantly improves analytical robustness for these samples compared to room‑temperature SIMS workflows. 

    What are the advantages of NanoSIMS Cryo for life sciences workflows?

    In life sciences, NanoSIMS Cryo enables quantitative sub‑cellular mapping of isotopes and elements in frozen cells and tissues. It supports applications such as metabolic tracing, pharmacokinetics, ion homeostasis, and cell signaling, providing chemical information that is complementary to structural techniques like Cryo‑EM. 

    How does NanoSIMS Cryo support advanced materials and soft‑matter research?

    For advanced materials and soft matter, NanoSIMS Cryo allows the study of emulsions, polymers, batteries, geological fluids, and atmospheric‑sensitive materials in a preserved state. This enables researchers to correlate chemical heterogeneity, interfaces, and transport phenomena at the nanoscale—critical for formulation science, energy materials, and geoscience. 

    Can NanoSIMS Cryo be used beyond academic research?

    Yes. While initially driven by academic and governmental labs, NanoSIMS Cryo is increasingly relevant for industrial R&D in areas such as pharma, cosmetics, food science, energy materials, where understanding chemistry in the native state directly impacts product performance and development decisions.


  • See what the NanoSIMS can do +

  • Documentation & success stories +

  • View recents webinars +

    • Unlock Native Chemistry at the Nanoscale – Discover NanoSIMS Cryo

      Tuesday, July 7, 2026

      Exclusive webinar introducing our new NanoSIMS Cryo solution, designed to preserve samples in their native state while enabling high-resolution, high-sensitivity imaging. Presented by NanoSIMS Product Manager, Aurélien Thomen.
      ON DEMAND HERE
      Click here to view
    • Characterization of extraterrestrial materials at the sub-micrometer scale by NanoSIMS

      Wednesday, May 20, 2026

      Explore how NanoSIMS reveals the origin of extraterrestrial materials. Learn how presolar grains provide unique insights into stellar nucleosynthesis and the chemical evolution of our galaxy through high-resolution isotopic analysis.
      ON DEMAND HERE
      Click here to view
    • Imaging Microbial Life at the Nanoscale: How NanoSIMS Reveals Single-Cell Function

      Wednesday, February 4, 2026

      A special webinar celebrated the International Day of Women and Girls in Science. Dr. Niculina Musat showcased how NanoSIMS reveals single‑cell microbial activity within complex communities, highlighting key methods, recent advances, and real‑world case studies.
      ON DEMAND HERE
      Click here to view
    • Exploring radionuclide contamination using new 226Ra standards & high resolution NanoSIMS analysis

      Tuesday, September 23, 2025

      Webinar presented by Louise Darricau, Postdoctoral Researcher at the ASNR and the MNHN, highlights how NanoSIMS technology enables precise isotopic imaging and quantification at the sub-micron scale, offering new possibilities for environmental and nuclear safety research.
      ON DEMAND HERE
      Click here to view
    • Revealing the intracellular distributions of biomolecules with a novel NanoSIMS-based methodology

      Tuesday, June 18, 2024

      Melanie Brunet, Ph.D. candidate in the Department of Chemical and Biomolecular Engineering at the University of Illinois Urbana−Champaign, working under the guidance of Prof. Mary Kraft, will introduce you to new NanoSIMS-based methodology that significantly enhances the accuracy of intracellular biomolecule visualization. Key take aways include: • Advanced Depth Correction • Accuracy in Imaging • Validation and Impact • Research Applications. .
      Duration: 30 minutes
      Click here to view
  • NanoSIMS users around the world +

    Below are links to some of our NanoSIMS Users
    If your site is not listed and you would like to appear on this page, please contact cameca.info@ametek.com.

    Stanford Nano Shared Facilities (SNSF), CA, USA
    NSF provides shared scientific instrumentation, laboratory facilities, and expert staff support to enable multidisciplinary research and educate tomorrow’s scientists and engineers.

    NASA, Astromaterials Research & Exploration Science, Houston TX, USA
    The ARES scientists are dedicated to astromaterials research (meteorites, cosmic and interplanetary dust, solar wind, and lunar rocks), exobiology & organic geochemistry. They use a NanoSIMS 50L to uncover insights on processes of early solar system and stellar evolution.

    Lawrence Livermore National Laboratory, California, USA
    The NanoSIMS at LLNL is used in groundbreaking microbiological research: it helps studying microbial nitrogen and carbon fixation, and carbon cycling, investigating forensic signatures in bacterial spores, vegetative cells, viruses, as well as a range of nuclear materials..

    CalTech Center for Microanalysis, USA
    The Center for Microanalysis at Caltech houses a NanoSIMS 50L and an IMS 7f-GEO, providing expertise for microanalysis of geological, meteoritic and synthetic materials. Research projects carried out at CCM are most varied, ranging from cosmochemistry to experimental studies on climate change, geochronology, in-situ studies of microbial communities, materials science engineering, and more...

    Center for NanoImaging, Brigham and Women's Hospital, USA
    Our mission is to extend multi-isotope imaging mass spectrometry – or MIMS – to new areas of biology and biomedical research, including with human translational studies conducted at the Brigham and Women’s Hospital and collaborating medical centers.

    Arizona State University, Tempe, USA
    Funded by the National Science Foundation and ASU, the NanoSIMS lab at ASU is mainly in space sciences, to investigate the chemistry of asteroids and comets.

    Washington University in Saint-Louis, MI, USA
    The Laboratory for Space Sciences at Washington University received the first NanoSIMS in 2000. Research projects cover presolar grains, interplanetary dust particles, meteorite geochemistry etc.

    Environmental Molecular Science Laboratory, Richland, WA, USA
    EMSL, a national scientific user facility at Pacific Northwest National Laboratory has been equipped with a NanoSIMS 50L model since 2011.

    Manchester University, School of Materials, UK
    The NanoSIMS 50L is a major component of the Multi-Disciplinary Characterisation Facility, and is applied across a wide range of projects in advanced materials research, geological investigations of interest to the nuclear,oil and gas sectors, as well as the study of extra-terrestrial materials, but also tracing biochemical processes in microbes and plants.

    Open University, UK
    The NanoSIMS 50L lab in Milton Keynes is managed by Dr I.A. Franchi, and used primarily for characterizing fine grained material and cometary dust particles collected in the stratosphere.

    The Department of Materials, University of Oxford, UK
    The CAMECA NanoSIMS 50 is an ultra high resolution chemical imaging facility combining the sensitivity of a dynamic SIMS with a lateral resolution of about 100nm. Our machine was delivered in August 2002 and is used on a very wide range of projects in the analysis of metallic, semiconducting, polymeric and biological materials....

    National Physical Laboratory (NPL), UK
    NPL is home to the National Centre of Excellence in Mass Spectrometry Imaging (NiCE-MSI), which aims to advance the development, understanding and application of the principal mass spectrometry imaging techniques. NPL researchers use the NanoSIMS 50L to support customers in healthcare, life sciences and other industries.

    Max Planck Institute for Chemistry, Cosmochemistry Department, Mainz, Germany
    The Cosmochemistry Department consists of several groups of scientists and technical personnel whose research interests and activities span a wide variety of fields in cosmochemical and space sciences. Many abstracts in the astrophysics field, downloadable in pdf format

    Max Planck Institut, Bremen, Germany

    The Max Planck Institute for Marine Microbiology of Bremen hosts the first NanoSIMS dedicated to environmental microbiology.

    Leibniz Institute for Baltic Sea Research (IOW), Warnemünde, Germany
    The NanoSIMS 50L at IOW is applied to a wide range of research fiels from microbiology and medicine to particle analysis and soil science.

    TUM: Technische Universität München, Germany
    Research Department Ecology and Ecosystem Management. Soil is the focal and connecting link between the information, matter and energy cycles of the hydrogeosphere and the atmosphere. Soil organic matter, clay sized particles and iron oxides are the most important reactants in soils building a complex physico-chemical interface. (…)

    Helmholtz Centre for Environmental Research – UFZ Leipzig, Germany
    Department of Isotope Biogeochemistry.
    What is the role of biogeochemical processes in the functionality of sustainably managed ecosystems? How can stable isotope readings assist the understanding of the fate of chemicals in anoxic environments such as soil-aquifer systems, freshwater and deep-sea sediments and bioreactors?

    University Medical Center Goettingen (UMG), Germany
    The University of Göttingen NanoSIMS was acquired in 2017 to equip the Center for Biostructural Imaging of Neurodeegneration (BIN).It is mainly applied to  the imaging of specific biological organelles, and thus provides insights into local protein and organelle turnover in a variety of cells and tissues.

    Faculty of Life Science, University of Vienna, Austria
    Inaugurated in February 2010, the NanoSIMS 50L lab is located within the Core Facility for Advanced Isotope Research. Under leadership from Michael Wagner, the Department of Microbial Ecology is one of the world leading center for single cell microbiology and the study of microorganisms in selected ecosystems.

    UPFL: Université Polytechnique Fédérale de Lausanne, Switzerland
    Laboratory for Biological Geochemistry LGB. Established in 2012, the LBG currently consists of about 15 Senior Scientists, Postdocs, PhD- and Master students working on research projects at the interface between isotope geochemistry, mineralogy and biology.

    LIST, Luxembourg institute of Science and Technology, Luxembourg
    The Luxembourg Institute of Science and Technology (LIST) is a mission-driven Research and Technology Organisation (RTO) that develops advanced technologies and delivers innovative products and services to industry and society.

    Utrecht University, Netherlands
    Since summer 2013 Utrecht University hosts the Dutch national facility for high-resolution in situ isotope and element analysis of natural materials, supporting research in biogeochemistry and (microbial) ecology, paleo-environmental and climate reconstructions, planetary and solid earth sciences.
    > Watch video on NanoSIMS

    Institut de Minéralogie, de Physique des Matériaux et de Cosmochimie (IMPMC), Paris, France
    The IMPMC is particularly notable in its multidisciplinary approach. This means most topics are studied by researchers from different backgrounds—in physics, Earth science or biology. Experimental platforms, technical know-how and scientific expertise are all used to conduct research on the interactions between the living world (including bacteria) and the mineral world.

    Institut Curie, Orsay, France
    Analytical Imaging of the Cell by Secondary Ion Mass Spectroscopy (SIMS microscopy). Introduction: "Of the various analytical methods developed in microscopy during the latter half of the century, SIMS imaging is probably one of the most powerful and sophisticated. Originally introduced..." Link to full article.

    Groupe de Physique des Matériaux (GPM), Rouen, France
    The NanoSIMS at GPM supports multidisciplinary projects in the field of health and environment: human exposure to nanoparticles and their dispersion in the environment, interactions of (nano)particles with living organisms in connection with toxicological and cosmetological studies.

    IPREM, Université of Pau, France

    The NanoSIMS 50L at Institute of Analytical Sciences and Physico-Chemistry for Environment and Materials (IPREM) is the first one equipped with the new RF Plasma oxygen ion source. It is mainly used for the localization of metals at catalyst surfaces or the imaging of essential and toxic trace metals in biological cells.

    Chemical Imaging Infrastructure of the Gothenburg University and Chalmers University of Technology, Sweden
    The NanoSIMS 50L in Gothenburg is the first of these instruments in Scandinavia. The NanoSIMS is suitable for a wide variety of applications such as grain boundary analysis, characterization of stress corrosion cracking, sub-cellular drug/peptide imaging and nitrogen fixation studies in bacteria.

    Physical Research Laboratory, India
    Known as the cradle of Space Sciences in India, the Physical Research Laboratory (PRL) was founded in 1947 by Dr. Vikram Sarabhai. As a unit of the Department of Space, Government of India, PRL carries out fundamental research in select areas of Physics, Space & Atmospheric Sciences, Astronomy, Astrophysics & Solar Physics, and Planetary & Geosciences.

    IGGCAS, Beijing, China
    The Institute of Geology and Geophysics, Chinese Academy of Sciences houses a NanoSIMS 50L in addition to its 2 large-geometry SIMS (IMS 1280 and IMS 1280-HR). The NanoSIMS was acquired to promote research in space sciences and is meant to play a major role in the analysis of lunar samples retrieved by Chinese lunar exploration missions.

    Academia Sinica, Taipei, Taiwan
    The NanoSIMS Laboratory was established in 2013 by a cooperative effort between Institute of Astronomy and Astrophysics and the Institute of Earth Science of Academia Sinica. Primarily designed to probe the early Solar System by analyzing extraterrestrial and terrestrial samples, the laboratory is also involved in numerous interdisciplinary collaborations with both domestic and international research groups covering cosmo, geo, life and material sciences.

    Kochi Institute for Core Research Sample, JAMSTEC, Japan
    The Isotope Geochemistry Group owns several CAMECA SIMS dedicated to the analysis of isotopes and trace elements in geological, environmental and biological samples to understand water-rock interactions, geologic processes, global & regional geochemical cycles, and limits of subseafloor life.

    Toray Research Center, Japan
    Established in 2018, the NanoSIMS 50 L lab offers analytical service in semiconductor, ceramics, metal and life science areas.

    Centre for Microscopy, Characterization & Analysis, UWA, Perth, Autralia
    Established in 1970, the CMCA provides essential teaching and research infrastructure in ion, electron, laser and light microscopy and microanalysis to universities, goverment of Western Australia and local industry. It is now home to two CAMECA ion probes, the NanoSIMS 50 installed in 2003 and the more recently acquired IMS 1280.

  • Software +

    • WinCurve dataprocessing sofware
      WinCurve

      Specifically developed for CAMECA SIMS instruments, WinCurve offers powerful data processing & visualization capabilities in a user-friendly environment.

      Keep Reading

    • WinImage Software
      WinImage II

      Specifically developed for CAMECA SIMS instruments, WinImage II offers powerful image visualization, processing & printing capabilities under PC-Windows™ Environment.

      Keep Reading

  • Scientific Publications +


    An Excel spreadsheet compiling scientific research articles using NanoSIMS data is available for download. The articles are ordered by main applications as below and are easily searchable with Excel word search functions:
    • Planetary Sciences
    • Geology
    • Geochronology
    • Paleobiology / Evolution
    • Atmospheric particles / Aerosols
    • Biomineralization / Paleoclimate
    • Environment / Nanoparticles
    • Soils
    • Plants
    • Environmental Microbiology
    • Microbiome / Microbiology
    • Cell Biology
    • Pharmacology / Cosmetics
    • Materials
    • Methods / Instrumentation
    Click here to download the NanoSIMS scientific articles compilation spreadsheet

    Do not hesitate to contact us at cameca.info@ametek.com if you can not access some pdf files by your own. You are also more than welcome to send us any missing references, pdf and supplements!