Subcellular Imaging of Anticancer Metallodrugs
Track and localize metallodrugs in biological systems using high-sensitivity SIMS techniques.
NanoSIMS: a new asset to maximize the chance of next-generation drugs by tracking them inside cells and subcellular compartments.
The NanoSIMS is Secondary Ion Mass Spectrometer enabling quantitative imaging as well as:
- (co)localizing drugs and biomolecules in subcellular compartments thanks to its 50 nm spatial resolution and 2D/3D imaging capability
- tracking up to 7 different biomolecules and drugs simultaneously by multiplexed imaging and elemental/isotopic labelling
- detecting trace amounts of drug and/or major biomolecules thanks to its 6 order of magnitudes dynamic range
By allowing the precise localization of added metal compounds and revealing sites of drug accumulation, the NanoSIMS opens new avenues for drug development.
Download to read this high impact research facilitated by the NanoSIMS.
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