NanoSIMS 50L
SIMS Microprobe for Isotopic and Trace Element Analysis at High Spatial Resolution
The NanoSIMS 50L is a unique ion microprobe optimizing SIMS analysis performance at high lateral resolution. It is based on a coaxial optical design of the ion beam and the secondary ion extraction, and on an original magnetic sector mass analyzer with multi-collection.
Product Details
The NanoSIMS 50L delivers simultaneously key performance metrics that can only be obtained individually with any other known instrument or technique:
High analysis spatial resolution (down to 50 nanometers)
High sensitivity (ppm in element imaging)
High Mass Resolution (M/dM)
Parallel acquisition of seven masses
Fast acquisition (DC mode, not pulsed)
Analysis of electrically insulating samples without problem
And thanks to recent improvements, isotope ratio reproducibility of a few tenths of per mil can now be achieved.
Extended fields of applications
Microbiology:
The NanoSIMS 50L opens new possibilities for coupling phylogenetic identity (with FISH or El-FISH) and metabolic function (using stable isotope labeling) of single cells in studies of mixed microbial communities from the environment.
Cell biology:
50 nm resolution and isotopic ratio capabilities of the NanoSIMS 50L allow intra-cellular measurement of accumulations and fluxes of molecules labeled with stable isotopes
Geology and space science:
The NanoSIMS 50L allows precise isotopic and elemental measurements of deep sub-micron areas, grains or inclusions from interplanetary dust particles, meteorites, and mineral sections. Working in multiple Faraday Cup configuration and with spot size of a few µm, it delivers isotope ratio measurements with precision and external reproducibility down to a few tenths of per mil.
Materials Research:
Thanks to its high sensitivity at high mass resolution (no mass interference), the NanoSIMS 50L allows trace element (dopant) imaging & quantification with 50 nm SIMS lateral resolution, even in electrically insulating materials. All elements except noble gases are accessible, from hydrogen to plutonium.
The NanoSIMS 50L was originally designed by Pr. G. Slodzian, University of Paris Sud, France.
Benefits
Discover the key advantages that set our solution apart. From increased efficiency to exceptional support, these benefits are designed to deliver real value and help you achieve more with confidence.
Webinars
Revealing the Intracellular Distributions of Biomolecules with a Novel NanoSIMS-based Methodology
Melanie Brunet, Ph.D. candidate in the Department of Chemical and Biomolecular Engineering at the University of Illinois Urbana−Champaign, working under the guidance of Prof. Mary Kraft, will introduce you to new NanoSIMS-based methodology that significantly enhances the accuracy of intracellular biomolecule visualization. Key take aways include: Advanced Depth Correction; Accuracy in Imaging; Validation and Impact; Research Applications.
Lithium-Ion Battery Research with NanoSIMS
Gina Greenidge, Higher Scientist at the National Physical Laboratory (NPL), UK’s National Metrology Institute, presents a study nitrogen fixation in maize leaf chloroplasts, or the role of vitamin B5 on cancer tumor proliferation. Key takeaways include: Review the capabilities of the NanoSIMS for nanoscale chemical mapping in LIB samples; Observe the collocation of fluorine and phosphorus, and the increase in Li, P and F signals for aged LIB samples; Gain insight into LIB anode degradation processes and the challenges that lie ahead for enabling batteries with longer life-time and higher performance.
NanoSIMS Imaging of the Brain in Health and Disease
In this webinar, Dr Silvio Rizzoli will present NanoSIMS Imaging of the Brain in Health and Disease.
Improving the Targeting of ASO Therapeutic by NanoSIMS Sub-cellular Imaging
Cécile Becquart, post-doctoral fellow at AstraZeneca, presents recent advances in Antisense Oligonucleotides (ASOs) and the use of NanoSIMS to image and quantify the distribution and accumulation of ASOs within cells. Key takeaways include: Review challenges in terms of delivery of ASOs to specific tissues and inefficient escape from endolysosomal compartments which restrict their use in the clinic; Understand the mechanisms underlying how ASOs enter cells and exit the endolysosomal space; Learn about the specifics NanoSIMS sub-cellular quantitative imaging.
Unveiling Drug Targets Inside the “Black Box” of the Cell with NanoSIMS
In this webinar, Michael Kurczy discusses the development of the DrugSIMS™ platform. From the original blue sky initiative to embed a NanoSIMS in a pharmaceutical company to the eventual intracellular quantification of nucleic acid based therapeutics.
Subcellular Measurements of Cell Turnover and Metabolism with NanoSIMS
Pr. Steinhauser reports on his investigation of metabolic processes including glucose, lipid and nucleic acid metabolism, and cell turnover with NanoSIMS.
Downloads
Application Note
Flyer
Success Story
White Paper
A New Approach Unveils Drug Targets Inside "Black Box" of Cell
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