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Life Science

Browse all applications for life science

Offering powerful instruments for imaging and analyzing intracellular metabolic pathways, DNA expression, virus penetration and drug localization, CAMECA enables important medical advancements. NanoSIMS is particularly adept for single cell imaging and increasingly used in neurochemistry, other SIMS instruments serve radiation protection, APT is also a powerful tool for atomic-scale analysis of biological interfaces.

radiation-protection-U-in-skin-SIMS

Life Science 

Radiation Protection: Uranium Diffusion Through Skin (SIMS)

Uranium is a radioactive heavy metal naturally present in earth crust. Internal contamination of nuclear workers by actinides such as uranium may occur either by inhalation, ingestion or penetration through wounds or intact skin, and the SIMS technique is used to assess uranium transfer through the skin. Experiments have been performed in order to characterize uranium bioaccumulation process at skin pig. The results suggest that the stratum corneum is a good defense barrier against the incorporation of the radionuclide into the skin, but can also constitute a reservoir for the diffusion of the radionuclide if no decontamination treatment is applied.

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protein-turnover-in-hair-cells-NanoSIMS

Life Science 

Cell Biology: Protein Turnover (NanoSIMS)

The NanoSIMS allows biologists to view and quantify protein turnover and to follow the fate of biomolecules with intra-cellular resolution.

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stem-cell-division-NanoSIMS

Life Science 

Cell Biology: Stem Cell Division Quantification (NanoSIMS)

Experiments involving stable isotope labeling and quantitative Multiple Isotope Mass Spectrometry with the NanoSIMS are conducted in order to test the immortal strand hypothesis.

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Life-science-tooth-APT-1000x1000

Life Science 

Biominerals: Analysis of Impurities in Tooth (APT)

Atom Probe Tomography allows 3-dimensional atomic-scale analysis of impurities in bones and teeth.

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NanoSIMS has even proven invaluable in the visualization and monitoring of therapeutic nanoparticles, thereby enhancing our knowledge of drug delivery mechanisms at the cellular level. "
Prof. Gary Siuzdak
Scripps Center for Metabolomics, USA
By applying SIMS to my samples from the Greenland Ice Sheet, I was able to generate single-cell measurements of microbial activity and nutrient uptake, revealing how these algae thrive in such a harsh environment and may expand across the ice in the future. The SIMS measurements provided the first single-cell data on carbon and nitrogen uptake in glacier ice algae, showing their minimal nutrient requirements and resilience in extreme environments. For me, this clearly highlights SIMS as a unique and powerful method for quantifying microbial activity and advancing our understanding of elemental cycling. "
Dr. Laura Halbach
Max-Planck-Institute for Marine Biology, Bremen, Germany
Our IMS 7f instrument was just being installed when the 3rd November 2011 earthquake happened. Despite seismic intensity of 7 and subsequent nuclear plant trouble, our university being located 100 km from Fukushima, CAMECA staff could solve the vibration related molecular pump issues and perfectly install the instrument. Since then, the Tohoku University IMS 7f has proven to be a robust machine, stable over time and incredibly versatile. We use it successfully for a wide variety of challenging microanalytical tasks such as characterization of diffusion in solid materials for fuel cells, depth profiles for multi layers in electric devices, behaviors of additional elements in steels or ceramics, dating in geoscience, isotopes analysis in biology. "
Dr. Takamichi Miyazaki
Tohoku University School of Engineering, Japan

Related Resources

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We offer training for all instruments and experience levels, available online or at your lab. CAMECA accelerates your learning curve!

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We offer a range of post-warranty service solutions to suit various customer requirements: several annual maintenance service contracts are available as well as attractive on-demand solutions, allowing our customers to focus on their core activity - and leave their maintenance needs and worries to us.