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NanoSIMS Publications

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Atmospheric particles / Aerosols

Speciation of nitrogen bearing species using negative and positive secondary ion spectra with Nano Secondary Ion Mass Spectrometry. Kexue Li, Barbel Sinha, Peter Hoppe, Analytical Chemistry February 2016.
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Sea salt aerosols as a reactive surface for inorganic and organic acidic gases in the Arctic troposphere. J. W. Chi, W. J. Li, D. Z. Zhang, J. C. Zhang, Y. T. Lin, X. J. Shen, J. Y. Sun, J. M. Chen, X. Y. Zhang, Y. M. Zhang, and W. X. Wang. Atmospheric Chemistry and Physics, 15, 11341–11353, 2015.
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In-cloud sulfate addition to single particles resolved with sulfur isotope analysis during HCCT 2010. Harris E. et al. Atmos. Chem. Phys. 14, 4219-4245.

Spatially resolved chemical imaging of individual atmospheric particles using nanoscale imaging mass spectrometry: insight into particle origin and chemistry.
Sutapa Ghosal, Peter K. Weber and Alexander Laskin. Analytical Methods, 13 Jan 2014. DOI: 10.1039/c3ay42012d
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Enhanced Role of Transition Metal Ion Catalysis During In-Cloud Oxidation of SO2.
Eliza Harris, Bärbel Sinha, Dominik van Pinxteren, Andreas Tilgner, Khanneh Wadinga Fomba, Johannes Schneider, Anja Roth, Thomas Gnauk, Benjamin Fahlbusch, Stephan Mertes, Taehyoung Lee, Jeffrey Collett, Stephen Foley, Stephan Borrmann, Peter Hoppe, Hartmut Herrmann. Science May 10, 2013.
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Biogenic potassium salt particles as seeds for secondary organic aerosol in the amazon.
Pöhlker C, Wiedemann KT, Sinha B, Shiraiwa M, Gunthe SS, Smith M, Su H, Artaxo P, Chen Q, Cheng Y, Elbert W, Gilles MK, Kilcoyne AL, Moffet RC, Weigand M, Martin ST, Pöschl U, Andreae MO. Science (New York, N.Y.) 337:6098 2012 Aug 31 pg 1075-8.
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Sulfur isotope analyses of individual aerosol particles in the urban aerosol at a central European site (Mainz, Germany).
Baerbel.W. Sinha, P. Hoppe, J. Huth, S. Foley, and M. O. Andreae. Atmospheric Chemistry and Physics, 8, 7217–7238, 2008
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Sulfur isotope ratio measurements of individual sulfate particles by NanoSIMS.
Baerbel Winterholler, Peter Hoppe, Stephen Foley, Meinrat O. Andreae. Int J Mass Spectrom 272: 63 – 77
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Biomineralization / Paleoclimate

Fe biomineralization mirrors individual metabolic activity in a nitrate-dependent Fe(II)-oxidizer. Miot J, Remusat L, Duprat E, Gonzalez A, Pont S, Poinsot M. Front Microbiol. 2015 Sep 8;6:879. doi: 10.3389/fmicb.2015.00879. eCollection 2015.
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Biomineralization mediated by anaerobic methane-consuming cell consortia. Ying Chen, Yi-Liang Li, Gen-Tao Zhou, Han Li, Yang-Ting Lin, Xiang Xiao & Feng-Ping Wang. Scientific Reports 4, Article number: 5696 (2014) doi:10.1038/srep05696
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Ultrascale and Microscale Growth Dynamics of the Cidaroid Spine of Phyllacanthus imperialis Revealed by 26Mg Labeling and NanoSIMS Isotopic Imaging.
Przemysław Gorzelak, Jarosław Stolarski, Aurelie Dery, Philippe Dubois, Stephane Escrig, and Anders Meibom. Journal of Morphology 275:788–796 (2014)
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Viruses as new agents of organomineralization in the geological record. Muriel Pacton, David Wacey, Cinzia Corinaldesi, Michael Tangherlini, Matt R. Kilburn, Georges E. Gorin, Roberto Danovaro & Crisogono Vasconcelos. Nature Communications, 5: 4298, 3 July 2014
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Templated Biomineralization on Self-Assembled Protein Nanofibers Buried in Calcium Oxalate Raphides of Musa spp. Xiuli Li, Wenjun Zhang, Jianwei Lu, Lixue Huang, Defeng Nan, Mary Alice Webb, Francois Hillion, and Lijun Wang. Chem. Mater. 2014, 26, 3862−3869
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Simultaneous extension of both basic microstructural components in scleractinian coral skeleton during night and daytime, visualized by in situ 86Sr pulse labeling. I. Domart-Coulon, J. Stolarski, C. Brahmi, E. Gutner-Hoch, K. Janiszewska, A. Shemesh, A. Meibom. Journal of Structural Biology 185 (2014) 79–88.
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Unusual Micrometric Calcite–Aragonite Interface in the Abalone Shell Haliotis (Mollusca, Gastropoda). Yannicke Dauphin, Jean-Pierre Cuif, Hiram Castillo-Michel, Corinne Chevallard, Bastien Farre and Anders Meibom. Microsc. Microanal. Page 1 of 9. September 30, 2013. DOI: 10.1017/S1431927613013718
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Micro- to nanostructure and geochemistry of extant crinoidal echinoderm skeletons. P. Gorzelak, J . Stolarski, M. Mazur and A. Meibom. Geobiology (2013), 11, 29–43. DOI: 10.1111/gbi.12012
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A new model for biomineralization and trace-element signatures of Foraminifera tests. G. Nehrke, N. Keul, G. Langer, L. J. de Nooijer, J. Bijma, and A. Meibom. Biogeosciences, 10, 6759–6767, 2013. DOI:10.5194/bg-10-6759-2013
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Microscale neodymium distribution in sedimentary planktonic foraminiferal tests and associated mineral phases. Kazuyo Tachikawa, Takashi Toyofuku, Isabelle Basile-Doelsch, Thomas Delhaye. Geochimica et Cosmochimica Acta 100 (2013) 11–23.
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Characterizing the microstructure of Arctica islandica shells using NanoSIMS and EBSD. Graeme B. Karney, Paul G. Butler, Susannah Speller, James D. Scourse, Christoper A. Richardson, Markus Schröder, Gareth M. Hughes, Jan T. Czernuszka, and Chris R. M. Grovenor. Geochemistry Geophysics Geosystems G3, Vol 13, 7 April 2012 
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Skeletal growth dynamics linked to trace-element composition in the scleractinian coral Pocillopora damicornis. Chloe Brahmi, C. Kopp, I. Domart-Coulon, J. Stolarski, Anders Meibom. Geochimica et Cosmochimica Acta 99 (2012) 146–158.
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Past daily light cycle recorded in the strontium/calcium ratios of giant clam shells. Sano Y, Kobayashi S, Shirai K, Takahata N, Matsumoto K, Watanabe T, Sowa K, Iwai K. Nat Commun. 2012 Mar 27;3:761. doi: 10.1038/ncomms1763 (2012)
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Going nano: a new step towards understanding the processes governing freshwater ooid formation. M. Pacton, D. Ariztegui, D. Wacey, M.R. Kilburn, C. Rollion-Bard, R. Farah, and C. Vasconcelos. Geology, June 2012 548-550
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Calcareous sponge biomineralization: Ultrastructural and compositional heterogeneity of spicules in Leuconia johnstoni Carter, 1871. Christophe Kopp, Anders Meibom, Olivier Beyssac, Jarosław Stolarski, Shakib Djediat, Jakub Szlachetko, Isabelle Domart-Coulon. Journal of Structural Biology 173 (2011) 99–109.
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26Mg labeling of the sea urchin regenerating spine: Insights into echinoderm biomineralization process. Przemysław Gorzelak, Jarosław Stolarski, Philippe Dubois, Christophe Kopp, Anders Meibom. Journal of Structural Biology 176 (2011) 119–126. DOI:10.1016/j.jsb.2011.07.008
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NanoSIMS: Insights into the Organization of the Proteinaceous Scaffold within Hexactinellid Sponge Spicules. Werner E. G. Müller, Xiaohong Wang Bärbel Sinha, Matthias Wiens, Heinz-C. Schrçder, and Klaus Peter Jochum. ChemBioChem 2010, 11, 1077 – 1082, DOI: 10.1002/cbic.201000078.
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Desulfovibrio magneticus RS-1 contains an iron- and phosphorus-rich organelle distinct from its bulletshaped magnetosomes. Meghan E. Byrne, D. A. Ball, J-L Guerquin-Kern, Isabelle Rouiller, Ting-Di Wu, Kenneth H. Downing, Hojatollah Vali, and Arash Komeili. PNAS, July 6, 2010, vol. 107, no. 27, pages 12263–12268.
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A Layered Structure in the Organic Envelopes of the Prismatic Layer of the Shell of the Pearl Oyster Pinctada margaritifera (Mollusca, Bivalvia). Y. Dauphin, A. Brunelle, M. Cotte, J.P. Cuif, B. Farre, O. Laprévote, A. Meibom, M. Salomé, and C.T. Williams. Microsc. Microanal. 16, 91–98, 2010
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Skeletal growth, ultrastructure and composition of the azooxanthellate scleractinian coral Balanophyllia regia. C. Brahmi, A. Meibom, D. C. Smith, J. Stolarski, S. Auzoux-Bordenave, J. Nouet, D. Doumenc, C. Djediat, I. Domart-Coulon. Coral Reefs (2010) 29:175–189. 
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Dynamics of sheet nacre formation in bivalves. Marthe Rousseau, Anders Meibom, Marc Gèze, Xavier Bourrat, Martine Angellier, Evelyne Lopez. Journal of Structural Biology 165 (2009) 190-195
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Strontium-86 labeling experiments show spatially heterogeneous skeletal formation in the scleractinian coral Porites porites. Fanny Houlbreque, A. Meibom, J-P. Cuif, J. Stolarski, Y. Marrocchi, C. Ferrier-Pages, I. Domart-Coulon, R.B. Dunbar. Geophysical Research Letters, Vol. 36, L04604, 2009
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The grinding tip of the sea urchin tooth exhibits exquisite control over calcite crystal orientation and Mg distribution. Yurong Ma, Barbara Aichmayer, Oskar Paris, Peter Fratzl, Anders Meibom, Rebecca A. Metzler, Yael Politi, Lia Addadi, P. U. P. A. Gilbert, and Steve Weiner. 6048–6053, PNAS, April 14, 2009, vol. 106, no. 15. DOI: 10.1073/pnas.0810300106
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Minor and trace element incorporation into branching coral Acropora nobilis skeleton. Kotaro Shirai, Tatsunori Kawashima, Kohki Sowa, Tsuyoshi Watanabe, Toru Nakamori, Naoto Takahata, Hiroshi Amakawa, Yuji Sano. Geochimica et Cosmochimica Acta 72 (2008) 5386–5400. doi:10.1016/j.gca.2008.07.026
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Structure and composition of the nacre–prisms transition in the shell of Pinctada margaritifera (Mollusca, Bivalvia).
Yannicke Dauphin, Alexander D. Ball, Marine Cotte, Jean-Pierre Cuif, Anders Meibom, Murielle Salomé, Jean Susini and C. Terry Williams. Anal Bioanal Chem (2008) 390:1659–1669. DOI: 10.1007/s00216-008-1860-z
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Compositional variations at ultra-structure length scales in coral skeleton. Anders Meibom, Jean-Pierre Cuif, Fanny Houlbreque, Smail Mostefaoui, Yannicke Dauphin, Karin L. Meibom, Robert Dunbar. Geochimica et Cosmochimica Acta 72 (2008) 1555–1569. DOI:10.1016/j.gca.2008.01.009
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Novel analytical approach to bivalve shell biogeochemistry: A case study of hydrothermal mussel shell. Kotari Shirai, Naoto Takahata, Hiroyuki Yamamoto, Tamano Omata, Takenori Sasaki and Yuji Sano. Geochemical Journal, Vol. 42, pp. 413 to 420, 2008.
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Light and temperature effects on Sr/Ca and Mg/Ca ratios in the scleractinian coral Acropora sp. Stéphanie Reynaud, Christine Ferrier-Pagès, Anders Meibom, Smail Mostefaoui, Richard Mortlock, Richard Fairbanks, Denis Allemand. Geochimica et Cosmochimica Acta 71 (2007) 354–362. DOI:10.1016/j.gca.2006.09.009
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Biological forcing controls the chemistry of reef-buiding coral skeleton. Anders Meibom, S. Mostefaoui, J-P. Cuif, Y. Dauphin, F. Houlbreque, R. Dunbar, B. Constantz, Geophysical Research letter, vol 34, L02601, 2007.

Electron and ion microprobe analysis of calcium distribution and transport in coral tissues. Alan T. Marshall, Peta L. Clode, Robert Russell, Kathryn Prince, Richard Stern. The Journal of Experimental Biology 210, 2453-2463, 2007

Microdistribution of Mg/Ca, Sr/Ca, and Ba/Ca ratios in Pulleniatina obliquiloculata test by using a NanoSIMS: Implication for the vital effect mechanism. Daisuke Kunioka, Kotaro Shirai, Naoto Takahata, Yuji Sano, Takashi Toyofuku, Yurika Ujiie. G3, Volume 7, Number 12, 14 December 2006

Distribution of magnesium in coral skeleton. Anders Meibom, J-P Cuif, F. Hillion, B. R. Constanz, A. Juillet-Leclerc, Y.Dauphin, T. Wanatabe, R.B. Dunbar. Geophysical Research Letter, vol. 13, L23306, 2004      

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Environmental Microbiology

Establishment of stable synthetic mutualism without co-evolution between microalgae and bacteria demonstrated by mutual transfer of metabolites (NanoSIMS isotopic imaging) and persistent physical association (Fluorescent in situ hybridization). Luz E de-Bashan, Xavier Mayali, Brad M. Bebout, Peter Kilian Weber, Angela M. Detweiler, Juan- Pablo Hernandez, Leslie Prufert-Bebout, Yoav BashanAlgal Research 15:179-186 · April 2016

Single cell activity reveals direct electron transfer in methanotrophic consortia. Shawn E. McGlynn, Grayson L. Chadwick, Christopher P. Kempes & Victoria J. Orphan. Nature 526, 531–535
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Coexistence of Fe(II)- and Mn(II)-oxidizing bacteria govern the formation of deep sea umber deposits. Xiaotong Peng, Kaiwen Ta, Shun Chen, Lijuan Zhang, Hengchao Xu. Geochimica et Cosmochimica Acta. Volume 169, 15 November 2015, Pages 200–216
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Activity and interactions of methane seep microorganisms assessed by parallel transcription and FISH-NanoSIMS analyses. Anne E Dekas, Stephanie A Connon, Grayson L Chadwick, Elizabeth Trembath-Reichert and Victoria J Orphan. The ISME Journal online publication 22 September 2015; doi: 10.1038/ismej.2015.145
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In situ phenotypic heterogeneity among single cells of the filamentous bacterium Candidatus Microthrix parvicella. Abdul R Sheik, Emilie EL Muller, Jean-Nicolas Audinot, Laura A Lebrun, Patrick Grysan, Cedric Guignard and Paul Wilmes. The ISME Journal online publication 27 October 2015; doi: 10.1038/ismej.2015.181
 > Download pdf (3.6 MB)

Cyanobacterial reuse of extracellular organic carbon in microbial mats. Rhona K Stuart, Xavier Mayali, Jackson Z Lee, R Craig Everroad, Mona Hwang, Brad M Bebout, Peter K Weber, Jennifer Pett-Ridge and Michael P Thelen.. The ISME Journal online publication 23 October 2015; doi: 10.1038/ismej.2015.180
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Phenotypic heterogeneity in metabolic traits among single cells of a rare bacterial species in its natural environment quantified with a combination of flow cell sorting and NanoSIMS. Zimmermann M, Escrig S, Hübschmann T, Kirf MK, Brand A, Inglis RF, Musat N, Müller S, Meibom A, Ackermann M, Schreiber F. Front Microbiol. 2015 Apr 16;6:243. doi: 10.3389/fmicb.2015.00243.
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Exploring deep microbial life in coal-bearing sediment down to ~2.5 km below the ocean floor.
F. Inagaki, K.-U. Hinrichs, Y. Kubo, et al. Science 24 July 2015. Vol. 349 no. 6246 pp. 420-424. DOI: 10.1126/science.aaa6882
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Light microenvironment and single-cell gradients of carbon fixation in tissues of symbiont-bearing corals. Daniel Wangpraseurt, Mathieu Pernice, Paul Guagliardo, Matt R Kilburn, Peta L Clode, Lubos Polerecky and Michael Kühl. The ISME Journal , (4 August 2015) | doi:10.1038/ismej.2015.133
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N2-fixation, ammonium release and N-transfer to the microbial and classical food web within a plankton community. Birgit Adam, Isabell Klawonn, Jennie B Svedén, Johanna Bergkvist, Nurun Nahar, Jakob Walve, Sten Littmann, Martin J Whitehouse, Gaute Lavik, Marcel M M Kuypers and Helle Ploug. The ISME Journal , (11 August 2015) | doi:10.1038/ismej.2015.126
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Revisiting N₂ fixation in Guerrero Negro intertidal microbial mats with a functional single-cell approach. Woebken D, Burow LC, Behnam F, Mayali X, Schintlmeister A, Fleming ED, Prufert-Bebout L, Singer SW, Cortés AL, Hoehler TM, Pett-Ridge J, Spormann AM, Wagner M, Weber PK, Bebout BM.. ISME J. 2015 Feb;9(2):485-96. doi: 10.1038/ismej.2014.144. Epub 2014 Oct 10.
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Methane oxidation coupled to oxygenic photosynthesis in anoxic waters. Jana Milucka, Mathias Kirf, Lu Lu, Andreas Krupke, Phyllis Lam, Sten Littmann, Marcel MM Kuypers and Carsten J Schubert. The ISME Journal , (13 February 2015) | doi:10.1038/ismej.2015.12
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Heavy water and (15) N labelling with NanoSIMS analysis reveals growth rate-dependent metabolic heterogeneity in chemostats. Kopf SH, McGlynn SE, Green-Saxena A, Guan Y, Newman DK, Orphan VJ. Environ Microbiol. 2015 Jul;17(7):2542-56. doi: 10.1111/1462-2920.12752. Epub 2015 Mar 27.
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Use of carbon monoxide and hydrogen by a bacteria–animal symbiosis from seagrass sediments.
Manuel Kleiner, Cecilia Wentrup, Thomas Holler, Gaute Lavik, Jens Harder, Christian Lott, Sten Littmann, Marcel M. M. Kuypers and Nicole Dubilier. Environmental Microbiology 23Jul 2015
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The effect of nutrients on carbon and nitrogen fixation by the UCYN-A–haptophyte symbiosis. Andreas Krupke, Wiebke Mohr, Julie LaRoche, Bernhard M Fuchs, Rudolf I Amann and Marcel MM Kuypers. The ISME Journal 9, 1635-1647 (July 2015) | doi:10.1038/ismej.2014.253

Microbial carbon metabolism associated with electrogenic sulphur oxidation in coastal sediments. Vasquez-Cardenas D, van de Vossenberg J, Polerecky L, Malkin SY, Schauer R, Hidalgo-Martinez S, Confurius V, Middelburg JJ, Meysman FJ, Boschker HT. ISME J. 2015 Sep;9(9):1966-1978. doi: 10.1038/ismej.2015.10. Epub 2015 Feb 13.
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In situ visualization of newly synthesized proteins in environmental microbes using amino acid tagging and click chemistry. Roland Hatzenpichler, Silvan Scheller, Patricia L. Tavormina, Brett M. Babin, David A. Tirrell and Victoria J. Orphan. Environmental Microbiology (2014) 16(8), 2568–2590
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Biology of a widespread uncultivated archaeon that contributes to carbon fixation in the subsurface.
Alexander J. Probst, Thomas Weinmaier, Kasie Raymann, Alexandra Perras, Joanne B. Emerson, Thomas Rattei, Gerhard Wanner, Andreas Klingl, Ivan A. Berg, Marcos Yoshinaga, Bernhard Viehweger, Kai-Uwe Hinrichs, Brian C. Thomas, Sandra Meck, Anna K. Auerbach, Matthias Heise, Arno Schintlmeister, Markus Schmid, Michael Wagner, Simonetta Gribaldo, Jillian F. Banfield & Christine Moissl-Eichinger. Nature communications (2014) | 5:5497 | DOI: 10.1038/ncomms6497
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Tracking heavy water (D2O) incorporation for identifying and sorting active microbial cells. Berry D, Mader E, Lee TK, Woebken D, Wang Y, Zhu D, Palatinszky M, Schintlmeister A, Schmid MC, Hanson BT, Shterzer N, Mizrahi I, Rauch I, Decker T, Bocklitz T, Popp J, Gibson CM, Fowler PW, Huang WE, Wagner M. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):E194-203. doi: 10.1073/pnas.1420406112. Epub 2014 Dec 30.
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Growth of nitrite-oxidizing bacteria by aerobic hydrogen oxidation. Hanna Koch, Alexander Galushko, Mads Albertsen, Arno Schintlmeister, Christiane Gruber-Dorninger, Sebastian Lücker, Eric Pelletier, Denis Le Paslier, Eva Spieck, Andreas Richter, Per H. Nielsen, Michael Wagner, Holger Daims. Science Vol 345 issue 6200. 29 August 2014
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Spatial distribution of nitrogen fixation in methane seep sediment and the role of the ANME archaea. Anne E. Dekas, Grayson L. Chadwick, Marshall W. Bowles, Samantha B. Joye and Victoria J. Orphan. Environmental Microbiology (2014) 16(10), 3012–3029. doi:10.1111/1462-2920.12247
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Gold-ISH: A nano-size gold particle-based phylogenetic identification compatible with NanoSIMS. Kengo Kubota, Yuki Morono, Motoo Ito, Takeshi Terada, Shogo Itezono, Hideki Harada, Fumio Inagaki. Systematic and Applied Microbiology 37 (2014) 261–266.
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A nanoscale secondary ion mass spectrometry study of dinoflagellate functional diversity in reef-building corals. Mathieu Pernice, Simon R. Dunn, Linda Tonk, Sophie Dove, Isabelle Domart-Coulon, Peter Hoppe, Arno Schintlmeister, Michael Wagner and Anders Meibom. Environmental Microbiology (2014) doi:10.1111/1462-2920.12518
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The effect of FISH and CARD-FISH on the isotopic compositionof 13C- and15N-labeled Pseudomonas putida cells measuredby NanoSIMS. Niculina Musat, Hryhoriy Stryhanyuk, Petra Bombach, Lorenz Adrian,Jean-Nicolas Audinot, Hans H. Richnow. Systematic and Applied Microbiology xxx (2014) xxx–xxx
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Phylogenetic Patterns in the Microbial Response to Resource Availability: Amino Acid Incorporation in San Francisco Bay. Xavier Mayali, Peter K. Weber, Shalini Mabery, Jennifer Pett-Ridge. PLOS ONE, 1 April 2014, Volume 9, Issue 4
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Fermentation couples Chloroflexiand sulfate-reducing bacteria to Cyanobacteriain hypersaline microbial mats. Jackson Z.Lee, Luke C.Burow, Dagmar Woebken, R. Craig Everroad, Mike D. Kubo, Alfred M.Spormann, Peter K. Weber, Jennifer Pett-Ridge, Brad M. Bebout and Tori M. Hoehler Frontiers in Microbiology, February 2014, Volume 5, Article 61, 1
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Nitrate-based niche differentiation by distinct sulfate-reducing bacteria involved in the anaerobic oxidation of methane. A Green-Saxena, AE Dekas, NF Dalleska and VJ Orphan. The ISME Journal (2014) 8, 150–163. DOI:10.1038/ismej.2013.147
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Correlated SEM, FIB-SEM, TEM, and NanoSIMS Imaging of Microbes from the Hindgut of a Lower Termite: Methods for In Situ Functional and Ecological Studies of Uncultivable Microbes. Kevin J. Carpenter, Peter K. Weber, M. Lee Davisson, Jennifer Pett-Ridge, Michael I. Haverty, and Patrick J. Keeling. Microsc. Microanal. 19, 1490–1501, 2013. DOI:10.1017/S1431927613013482
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Responses of the coastal bacterial community to viral infection of the algae Phaeocystis globosa. Abdul R Sheik, Corina PD Brussaard, Gaute Lavik, Phyllis Lam, Niculina Musat, Andreas Krupke, Sten Littmann, Marc Strous and Marcel MM Kuypers. The ISME Journal (2013), 1–14
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In situ identification and N2 and C fixation rates of uncultivated cyanobacteria populations. Andreas Krupke, Niculina Musat, Julie LaRoche, Wiebke Mohr, Bernhard M. Fuchs, Rudolf I. Amann, Marcel M., M. Kuypers, Rachel A. Foster. Systematic and Applied Microbiology, June, 2013.
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Measuring carbon and N2 fixation in field populations of colonial and free-living unicellular cyanobacteria using nanometer-scale secondary ion mass spectrometry.
Rachel A. Foster, Saar Sztejrenszus, Marcel M., M. Kuypers. Phycological Society of America, 25 March, 2013.
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Highly dynamic cellular-level response of symbiotic coral to a sudden increase in environmental nitrogen. Kopp C, Pernice M, Domart-Coulon I, Djediat C, Spangenberg JE, Alexander DTL, Hignette M, Meziane T, Meibom A. mBio, May 14, 2013.
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Cell-Specific Thioautotrophic Productivity of Epsilon-Proteobacterial Epibionts Associated with Shinkaia crosnieri. Tomo-o Watsuji, Manabu Nishizawa, Yuki Morono, Hisako Hirayama, Shinsuke Kawagucci, Naoto Takahata, Yuji Sano, Ken Takai. PLOS ONE, October 2012, Volume 7, Issue 10, e46282
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NanoSIP: NanoSIMS Applications for Microbial Biology.
Ali Navid (ed.), Microbial Systems Biology: Methods and Protocols, Methods in Molecular Biology, vol. 881, DOI 10.1007/978-1-61779-827-6_13, # Springer Science+Business Media, LLC 2012, Chapter 13. By: Jennifer Pett-Ridge and Peter K. Weber.
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Viral infection of Phaeocystis globosa impedes release of chitinous star-like structures: quantification using single cell approaches. A. R. Sheik, C. P. D. Brussaard, G. Lavik, R. A. Foster, N. Musat, B. dam1 and M. M. M. Kuypers. Environmental Microbiology (2012)
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Anaerobic degradation of propane and butane by sulfate-reducing bacteria enriched from marine hydrocarbon cold seeps. Ulrike Jaekel, Niculina Musat, Birgit Adam, Marcel Kuypers, Olav Grundmann and Florin Musat. The ISME Journal (2012), 1–11
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Linking environmental processes to the in situ functioning of microorganisms by high-resolution secondary ion mass spectrometry (NanoSIMS) and scanning transmission X-ray microscopy (STXM).
Sebastian Behrens, Andreas Kappler and Martin Obst. Environmental Microbiology, 2012.
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Anoxic carbon flux in photosynthetic microbial mats as revealed by metatranscriptomics. Luke C Burow, Dagmar Woebken, Ian PG Marshall, Erika A Lindquist, Brad M Bebout, Leslie Prufert-Bebout, Tori M Hoehler, Susannah G Tringe, Jennifer Pett-Ridge, Peter K Weber, Alfred M Spormann, Steven W Singer. The ISME Journal (2012), p. 1–13
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Zero-valent sulphur is a key intermediate in marine methane oxidation. Jana Milucka, Timothy G. Ferdelman, Lubos Polerecky, Daniela Franzke, Gunter Wegener, Markus Schmid,3 Ingo Lieberwirth, Michael Wagner, Friedrich Widdel1 & Marcel M. M. Kuypers. NATURE 22 November 2012, volume 491, p. 541–546
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Unicellular Cyanobacterium Symbiotic with a Single-Celled Eukaryotic. Anne W. Thompson, Rachel A. Foster, Andreas Krupke, Brandon J. Carter, Niculina Musat, Daniel Vaulot, Marcel M. M. Kuypers, Jonathan P. Zehr. SCIENCE 21 September 2012, Vol. 337 no. 6101 pp. 1546-1550, DOI: 10.1126/science.1222700
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Identification of a novel cyanobacterial group as active diazotrophs in a coastal microbial mat using NanoSIMS analysis.
Dagmar Woebken, Luke C Burow, Leslie Prufert-Bebout, Brad M Bebout, Tori M Hoehler, Jennifer Pett-Ridge, Alfred M Spormann, Peter K Weber and Steven W Singer. The ISME Journal (2012), 1–13
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A single-cell view of ammonium assimilation in coral–dinoflagellate symbiosis. Mathieu Pernice, Anders Meibom, Annamieke Van Den Heuvel, Christophe Kopp, Isabelle Domart-Coulon, Ove Hoegh-Guldberg and Sophie Dove. The ISME Journal (5 January 2012), doi:10.1038/ismej.2011.196
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Carbon and nitrogen assimilation in deep subseafloor microbial cells. Yuki Morono, Takeshi Terada, Manabu Nishizawa, Motoo Ito, François Hillion, Naoto Takahata, Yuji Sano and Fumio Inagakia. PNAS November 8, 2011 vol. 108 no. 45 18295-18300.
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High-throughput isotopic analysis of RNA microarrays to quantify microbial resource use. Xavier Mayali, Peter K Weber, Eoin L Brodie, Shalini Mabery, Paul D Hoeprich and Jennifer Pett-Ridge. The ISME Journal (2011), 1–12
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Detecting metabolic activities in single cells, with emphasis on NanoSIMS. Niculina Musat, Rachel Foster, Tomas Vagner, Birgit Adam & Marcel M. M. Kuypers. FEMS Microbiol Rev (2011) 1–26
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Carbon, nitrogen and O2 fluxes associated with the cyanobacterium Nodularia spumigena in the Baltic Sea. Helle Ploug, Birgit Adam, Niculina Musat, Tim Kalvelage, Gaute Lavik, Dieter Wolf-Gladrow and Marcel MM Kuypers. The ISME Journal (2011), 1–10.
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Nitrososphaera viennensis, an ammonia oxidizing archaeon from soil. Maria Tourna, Michaela Stieglmeier, Anja Spang, Martin Könneke, Arno Schintlmeister, Tim Urich, Marion Engel, Michael Schloter, Michael Wagner, Andreas Richter, and Christa Schleper. PNAS approved March 31, 2011.
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Nitrogen fixation and transfer in open ocean diatom–cyanobacterial symbioses. Rachel A Foster, Marcel MM Kuypers, Tomas Vagner, Ryan W Paerl, Niculina Musat and Jonathan P Zehr. The ISME Journal (2011), 1–10.
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A Bacterium That Can Grow by Using Arsenic Instead of Phosphorus. Felisa Wolfe-Simon, Jodi Switzer Blum, Thomas R. Kulp, Gwyneth W. Gordon, Shelley E. Hoeft, Jennifer Pett-Ridge, John F. Stolz, Samuel M. Webb, Peter K. Weber, Paul C. W. Davies, Ariel D. Anbar, Ronald S. Oremland. SCIENCE, published online 2 December 2010. Sience.1197258
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Carbon and nitrogen fluxes associated with the cyanobacterium Aphanizomenon sp. in the Baltic Sea. Helle Ploug, Niculina Musat, Birgit Adam, Christina Moraru, Gaute Lavik, Tomas Vagner, Birgitta Bergman and Marcel Kuypers. The ISME Journal April 2010
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Identification of Diazotrophic Microorganisms in Marine Sediment via Fluorescence In Situ Hybridization Coupled to Nanoscale Secondary Ion Mass Spectrometry (FISH-NanoSIMS).
Anne E. Dekas and Victoria J. Orphan. Chapter 12 of: Methods in Enzymology, Vol. 486, Research on Nitrification and related processes, part A. Edited by Martin G. Klotz

Uptake visualization of deltamethrin by NanoSIMS and acute toxicity to the water flea Daphnia magna. T. Eybe, T. Bohn, J.N. Audinot, T. Udelhoven, H.M. Cauchie, H.N. Migeon, L. Hoffmann. Chemosphere 76 (2009) 134–140

Methods for unveiling cryptic microbial partnerships in nature. Victoria J Orphan. Current Opinion in Microbiology 2009, 12:1–7
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Deep-Sea Archaea fix and share nitrogen in methane-consuming microbial consortia. Anne E. Dekas, Rachel S. Poretsky, Victoria J. Orphan. SCIENCE, Vol 326, 16 october 2009
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Co-occurrence of denitrification and nitrogen fixation in a meromictic lake, Lake Cadagno (Switzerland). Hannah Halm, N. Musat, P. Lam, R. Langlois, F. Musat, S. Peduzzi, G. Lavik, C.J. Schubert, B. Singha, J. LaRoche and M. M. M. Kuypers. Environmental Microbiology (2009)
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Fixation and fate of C and N in the cyanobacterium Trichodesmium using nanometer-scale secondary ion mass spectrometry.
J. A. Finzi-Hart, J. Pett-Ridge, P. K. Weber, R. Popa, S. J. Fallon, T. Gunderson, I. D. Hutcheon, K. H. Nealson and D. G. Capone. PNAS April 14, 2009, vol. 106 no. 15, p.6345–6350
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NanoSIMS 50 elucidation of the natural element composition in structures of cyanobacteria and their exposure to halogen compounds. T. Eybe, J.N. Audinot, T. Bohn, C. Guignard, H.N. Migeon and L. Hoffmann. Journal of Applied Microbiology ISSN 1364-5072, 2008
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A single-cell view on the ecophysiology of anaerobic phototrophic bacteria. Niculina Musat, H. Halm, B. Winterholler, P. Hoppe, S. Peduzzi, F. Hillion,F. Horreard, R. Amann, B.B. Jørgensen, and M.M.M. Kuypers. PNAS, Nov. 18, 2008, vol.105, no.46 pages 17861–17866
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Linking microbial phylogeny to metabolic activity at the single-cell level by using enhanced element labeling-catalyzed reporter deposition Fluorescence In Situ Hybridization and nanometer-scale Secondary-Ion Mass Spectrometry. Sebastian Behrens,Tina Losekann, Jennifer Pett-Ridge, Peter K. Weber, Wing-On Ng, Bradley S. Stevenson, Ian D. Hutcheon, David A. Relman and Alfred M. Spormann. Applied and Environmental Microbiology, May 2008
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Simultaneous analysis of microbial identity and function using NanoSIMS. Tianlun Li, Ting-Di Wu, Laurent Mazéas, Laurent Toffin, Jean-Luc Guerquin-Kern, G. Leblon, Th. Bouchez. Environmental Microbiology (2007). On-line nov. 2007

Quantitative imaging of nitrogen fixation by individual bacteria within animal cells. Claude Lechene, Yvette Luyten, Gregory McMahon, Daniel L. Distel. SCIENCE, 14 sept 2007, vol 317

Carbon and nitrogen fixation and metabolite exchange in and between individual cells of Anabaena oscillarioides. Radu Popa, Peter K Weber, Jennifer Pett-Ridge, Juliette A Finzi, Stewart J Fallon, Ian D Hutcheon, K. H Nealson an d Douglas G Capone. The ISME Journal (2007) 1, 354–360 

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Identification of the Primary Lesion of Toxic Aluminum in Plant Roots. Peter M. Kopittke, Katie L. Moore, Enzo Lombi, Alessandra Gianoncelli, Brett J. Ferguson, F. Pax C. Blamey, Neal W. Menzies, Timothy M. Nicholson, Brigid A. McKenna, Peng Wang, Peter M. Gresshoff, George Kourousias, Richard I. Webb, Kathryn Green, and Alina Tollenaere . Plant Physiology , April 2015, Vol. 167, pp. 1402–1411
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Exploring the transfer of recent plant photosynthates to soil microbes: mycorrhizal pathway vs direct root exudation. Christina Kaiser, Matt R. Kilburn, Peta L. Clode, Lucia Fuchslueger, Marianne Koranda, John B. Cliff, Zakaria M. Solaiman and Daniel V. Murphy. New Phytologist (2015) 205: 1537–1551
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High-resolution secondary ion mass spectrometry analysis of carbon dynamics in mycorrhizas formed by an obligately myco-heterotrophic orchid. Jeremy Bougoure, Martha Ludwig, Mark Brundrett, John Cliff, Peta Clode, Matt Kilburn & Pauline Grierson. Plant, Cell and Environment (2014) 37, 1223–1230
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Stable isotope cellular imaging reveals that both live and degenerating fungal pelotons transfer carbon and nitrogen to orchid protocorms. Yukari Kuga, Naoya Sakamoto and Hisayoshi Yurimoto. New Phytologist (2014) 202: 594–605
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Subcellular metal imaging identifies dynamic sites of Cu accumulation in Chlamydomonas.
Hong-Hermesdorf A, Miethke M, Gallaher SD, Kropat J, Dodani SC, Chan J, Barupala D, Domaille DW, Shirasaki DI, Loo JA, Weber PK, Pett-Ridge J, Stemmler TL, Chang CJ, Merchant SS. Nat Chem Biol. 2014 Dec;10(12):1034-42. doi: 10.1038/nchembio.1662. Epub 2014 Oct 26.
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Imaging element distribution and speciation in plant cells.
Fang-Jie Zhao, Katie L. Moore, Enzo Lombi, and Yong-Guan Zhu. Trends in Plant Science March 2014, Vol. 19, No. 3
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Combined NanoSIMS and synchrotron X-ray fluorescence reveal distinct cellular and subcellular distribution patterns of trace elements in rice tissues.
Katie L. Moore, Yi Chen, Allison M. L. van de Meene, Louise Hughes, Wenju Liu, Tina Geraki, Fred Mosselmans, Steve P. McGrath, Chris Grovenor and Fang-Jie Zhao. New Phytologist (2014) 201: 104–115
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Localization of iron in rice grain using synchrotron X-ray fluorescence microscopy and high resolution secondary ion mass spectrometry.
Bianca Kyriacou, Katie L. Moore, David Paterson, Martin D. de Jonge, Daryl L. Howard, James Stangoulis, Mark Tester, Enzo Lombi, Alexander A.T. Johnson. Journal of Cereal Science 59 (2014) 173-180
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Competition between plant and bacterial cells at the microscale regulates the dynamics of nitrogen acquisition in wheat (Triticum aestivum).
David L. Jones, Peta L. Clode, Matt R. Kilburn, Elizabeth A. Stockdale and Daniel V. Murphy. New Phytologist (2013) doi: 10.1111/nph.12405
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Localisation of iron in wheat grain using high resolution secondary ion mass spectrometry.
Katie L. Moore, Fang-Jie Zhao, Cristina S. Gritsch, Paola Tosi, Malcolm J. Hawkesford, Steve P. McGrath, Peter R. Shewry, Chris R.M. Grovenor. Journal of Cereal Science 55 (2012) 183-187
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Elemental imaging at the nanoscale: NanoSIMS and complementary techniques for element localisation in plants.
Katie L. Moore, Enzo Lombi, Fang-Jie Zhao, Chris R. M. Grovenor. Anal Bioanal Chem (2012) 402: 3263–3273
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Visualization and localization of bromotoluene distribution in Hedera helix using NanoSIMS. Ronan Tartivel, Romuald Tatin, Thomas Delhaye, Arthur Maupas, Amaury Gendron, Samy Gautier, Olivier Lavastre. Chemosphere 89 (2012) 805–809
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Root uptake and phytotoxicity of nanosized molybdenum octahedral clusters.
Tangi Aubert, Agnès Burel, Marie-Andrée Esnault, Stéphane Cordier, Fabien Grasset, Francisco Cabello-Hurtado Journal of Hazardous Materials 219– 220 (2012) 111– 118
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High-resolution elemental localization in vacuolate plant cells by nanoscale secondary ion mass spectrometry.
Katharine E. Smart, J. Andrew C. Smith, Matt R. Kilburn, Barrie G. H. Martin, Chris Hawes and Chris R. M. Grovenor. The Plant Journal (2010) 63, 870–879.
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Use of phosphate to avoid uranium toxicity in Arabidopsis thaliana leads to alterations of morphological and physiological responses regulated by phosphate availability.
Julie Misson, Pascale Henner, Marcel Morello, Magali Floriani, Ting-Di Wu, Jean-Luc Guerquin-Kern, Laureline Février. Environmental and Experimental Botany 67 (2009) 353–362.
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Cadmium and zinc localization by SIMS in leaves of Populus deltoides (cv. Lena) grown in ametal polluted soil.
Aude Migeon, Jean-Nicolas Audinot, Tanja Eybe, Pierre Richaud, Blaudez Damien, Henri-Noel Migeon andMichel Chalot., June 2010, DOI 10.1002/sia.3445
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Application of nanoscale secondary ion mass spectrometry to plant cell research.
Matt R. Kilburn, David L. Jones, Peta L. Clode, John B. Cliff, Elizabeth A. Stockdale, Anke M. Herrmann and Daniel V. Murphy. Plant Signaling & Behavior 5:6, 760-762; June 2010; © 2010 Landes Bioscience
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High-Resolution Secondary Ion Mass Spectrometry Reveals the Contrasting Subcellular Distribution of Arsenic and Silicon in Rice Roots. Katie L. Moore, Markus Schroder, Zhongchang Wu, Barry G.H. Martin, Chris R. Hawes, Steve P. McGrath, Malcolm J. Hawkesford, Jian Feng Ma, Fang-Jie Zhao, and Chris R.M. Grovenor. Plant Physiology, June 2011, Vol. 156, pp. 913–92.
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Nitrogen Mineralization and Assimilation at Millimeter Scales. David D. Myrold, Jennifer Pett-Ridge, and Peter J. Bottomley in Methods in ENZYMOLOGY, Volume 496. Research on Nitrification and related processes, Part B. Chapter four, pp.91-115.

NanoSIMS and EPMA analysis of nickel localisation in leaves of the hyperaccumulator plant Alyssum lesbiacum.
K.E. Smart, M.R. Kilburn, C.J. Salter, J.A.C. Smith, C.R.M. Grovenor, International Journal of Mass Spectrometry 260 (2007) P.107–114
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NanoSIMS analysis of arsenic and selenium in cereal grain.
Katie L. Moore, Markus Schroder, Enzo Lombi, Fang-Jie Zhao, Steve P. McGrath, Malcolm J. Hawkesford, Peter R. Shewry and Chris R. M. Grovenor. New Phytologist (2010) 185: 434–445
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Incorporation of 13C labelled shoot residues in Lumbricus terrestris casts: A combination of transmission electron microscopy and nanoscale secondary ion mass spectrometry. A. Vidal, L. Remust, F. Watteau, S. Derenne, K. Quenea. Soil Biology and Biochemistry. Volume 93, February 2016, Pages 8–16
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Novel Sample Preparation Technique To Improve Spectromicroscopic Analyses of Micrometer-Sized Particles. Carmen Höschen, Till Höschen, Carsten W. Mueller, Johann Lugmeier, Stefan Elgeti, Thilo Rennert and Ingrid Kögel-Knabner. Environ. Sci. Technol. 2015, DOI: 10.1021/acs.est.5b01636
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Advancements in the application of NanoSIMS and Raman microspectroscopy to investigate the activity of microbial cells in soils. Eichorst SA, Strasser F, Woyke T, Schintlmeister A, Wagner M, Woebken D. FEMS Microbiol Ecol. 2015 Oct;91(10). pii: fiv106. doi: 10.1093/femsec/fiv106. Epub 2015 Aug 30.
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NanoSIMS investigation of glycine-derived C and N retention with soil organo-mineral associations. Pierre-Joseph Hatton, Laurent Remusat, Bernd Zeller, Elizabeth A. Brewer, Delphine Derrien. Biogeochemistry Letters, pp 1-11, First online: 15 September 2015.
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Mineral protection of soil carbon counteracted by root exudates.
Marco Keiluweit, Jeremy J. Bougoure, Peter S. Nico,,Jennifer Pett-Ridge, Peter K. Weber & Markus Kleber. Nature Climate Change 5, 588–595 (2015) doi:10.1038/nclimate2580
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Submicron structures provide preferential spots for carbon and nitrogen sequestration in soils.
Cordula Vogel, Carsten W. Mueller, Carmen Höschen, Franz Buegger, Katja Heister, Stefanie Schulz, Michael Schloter & Ingrid Kögel-Knabner. Nature Communications, 7 Jan 2014. DOI:10.1038/ncomms3947
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Carbon mineralizability determines interactive effects on mineralization of pyrogenic organic matter and soil organic carbon. Whitman T, Zhu Z, Lehmann J. Environ Sci Technol. 2014 Dec 2;48 (23):13727-34. doi: 10.1021/es503331y. Epub 2014 Nov 13.
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Understanding the fate and linkage of N and S in earthworm-engineered peat soil by coupling stable isotopes and nano-scale secondary ion mass spectrometry. Aurelien Gicquel, Andre-Jean Francez, Thomas Delhaye, gerard Gruau, Vincent Hallaire, Francoise Binet. Biogeochemistry, March 2012.
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A multi-scale approach to determine accurate elemental and isotopic ratios by nano-scale secondary ion mass spectrometry imaging. Hatton PJ, Remusat L, Zeller B, Derrien D. Rapid Commun Mass Spectrom. 2012 Jun 15;26(11):1363-71.
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NanoSIMS study of organic matter associated with soil aggregates: advantages, limitations, and combination with STXM. Remusat L, Hatton PJ, Nico PS, Zeller B, Kleber M, Derrien D. Environ Sci Technol. 2012 Apr 3;46(7):3943-9.
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In Situ Mapping of Nutrient Uptake in the Rhizosphere Using Nanoscale Secondary Ion Mass Spectrometry. Peta L. Clode, Matt R. Kilburn, David L. Jones, Elizabeth A. Stockdale, John B. Cliff III, Anke M. Herrmann, and Daniel V. Murphy. Plant Physiology, December 2009, Vol. 151, pp. 1751–1757.
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Nano-scale secondary ion mass spectrometry — A new analytical tool in biogeochemistry and soil ecology: A review article. Anke M. Herrmann, Karl Ritz, Naoise Nunan, Peta L. Clode, Jennifer Pett-Ridge, Matt R. Kilburn, Daniel V. Murphy, Anthony G. O’Donnell, Elizabeth A. Stockdale. Soil Biology & Biochemistry 39 (2007) 1835–1850 
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Cell Biology

Enabling dual cellular destinations of polymeric nanoparticles for treatment following partial injury to the central nervous system. I. Lozić, R.V. Hartz, C.A. Bartlett, J.A. Shaw, M. Archer, P.S.R. Naidu, N.M. Smith, S.A. Dunlop, K. Swaminathan Iyer, M.R. Kilburn, M. Fitzgerald. Biomaterials, Volume 74, January 2016, Pages 200-216.
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Unearthing the Antibacterial Mechanism of Medicinal Clay: A Geochemical Approach to Combating Antibiotic Resistance. Keith D. Morrison, Rajeev Misra & Lynda B. Williams. Scientific Report 6, 19043; doi: 10.1038/srep19043 (2016).
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Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila. Andrew P. Bailey, Grielof Koster, Christelle Guillermier, Elizabeth M.A. Hirst, James I. MacRae, Claude P. Lechene, Anthony D. Postle, and Alex P. Gould. Cell 163, 340–353, October 8, 2015
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No Evidence for Cardiomyocyte Number Expansion in Preadolescent Mice. Kanar Alkass , Joni Panula , Mattias Westman , Ting-Di Wu , Jean-Luc Guerquin-Kern , Olaf Bergmann. CELL, Volume 163, Issue 4, p1026–1036, 5 November 2015
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A contamination-insensitive probe for imaging specific biomolecules by secondary ion mass spectrometry. Selda Kabatas, Ingrid C. Vreja, Sinem K. Saka, Carmen Höschen, Katharina Kröhnert, Felipe Opazo, Silvio O. Rizzoli and Ulf Diederichsen. Chem. Commun., 2015,51, 13221-13224
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Hemagglutinin Clusters in the Plasma Membrane Are Not Enriched with Cholesterol and Sphingolipids. Robert L. Wilson, Jessica F. Frisz, Haley A. Klitzing, Joshua Zimmerberg, Peter K. Weber, Mary L. Kraft. Biophysical journal, Volume 108, Issue 7, 7 April 2015, Pages 1652–1659
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Imaging the time-integrated cerebral metabolic activity with subcellular resolution through nanometer-scale detection of biosynthetic products deriving from 13C-glucose. Yuhei Takado, Graham Knott , Bruno M. Humbel, Mojgan Masoodi, Stephane Escrig, Anders Meibom, Arnaud Comment, Journal of Chemical Neuroanatomy 69 (2015) 7–12

Changes in subtypes of Ca microdomains following partial injury to the central nervous system. Ivan Lozić, Carole A. Bartlett, Jeremy A. Shaw, K. Swaminathan Iyer, Sarah A. Dunlop, Matt R. Kilburn and Melinda Fitzgerald . Metallomics, 2014,6, 455-464
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Imaging liver and brain glycogen metabolism at the nanometer scale.
Takado Y, Knott G, Humbel BM, Escrig S, Masoodi M, Meibom A, Comment A. Nanomedicine. doi: 10.1016/j.nano.2014.09.007. Jan 2015
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Immunohistochemistry and mass spectrometry for highly multiplexed cellular molecular imaging. Levenson RM, Borowsky AD, Angelo M. Lab Invest. 2015 Apr;95(4):397-405. doi: 10.1038/labinvest.2015.
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Secondary-ion mass spectrometry of genetically encoded targets. Vreja IC, Kabatas S, Saka SK, Kröhnert K, Höschen C, Opazo F, Diederichsen U, Rizzoli SO. Angew Chem Int Ed Engl. 2015 May 4;54(19):5784-8. doi: 10.1002/anie.201411692.
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Free mRNA in excess upon polysome dissociation is a scaffold for protein multimerization to form stress granules. Bounedjah O, Desforges B, Wu TD, Pioche-Durieu C, Marco S, Hamon L, Curmi PA, Guerquin-Kern JL, Piétrement O, Pastré D. Nucleic Acids Res. 2014 Jul;42(13):8678-91. doi: 10.1093/nar/gku582
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Study of protein and RNA in dendritic spines using multi-isotope imaging mass spectrometry. H. Brismar, A. Aperia, L. Westin, J. Moy, M. Wang, C. Guillermier, J. C. Poczatek and C. Lechene. Surface and Interface Analysis. Volume 46, Issue S1, pages 158–160, November 2014
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Brain stem cell division and maintenance studied using multi-isotope imaging mass spectrometry (MIMS). Grigori Enikolopov, Christelle Guillermier, Mei Wang, Louise Trakimas, Matthew L. Steinhauser and Claude Lechene. Surface and Interface Analysis. Volume 46, Issue S1, pages 140–143, November 2014. Article first published online: 25 NOV 2014. DOI: 10.1002/sia.5675
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Effect of an antidepressant on mouse hippocampus protein turnover analyzed by MIMS. M. D. Filiou, J. Moy, M. Wang, C. Guillermier, J. C. Poczatek, C. W. Turck and C. Lechene. Surface and Interface Analysis. Volume 46, Issue S1, pages 144–146, November 2014. Article first published online: 28 JUL 2014. DOI: 10.1002/sia.5616
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Quasi-simultaneous acquisition of nine secondary ions with seven detectors on NanoSIMS50L: application to biological samples. Christelle Guillermier, Matthew L. Steinhauser and Claude P. Lechene. Surface and Interface Analysis. Volume 46, Issue S1, pages 150–153, November 2014. Article first published online: 7 MAY 2014. DOI: 10.1002/sia.5496
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Loss of White Adipose Hyperplastic Potential Is Associated with Enhanced Susceptibility to Insulin Resistance. Soo M. Kim, Mingyue Lun, Mei Wang, Samuel E. Senyo, Christelle Guillermier, Parth Patwari, Matthew L. Steinhauser. Cell Metabolism. Volume 20, Issue 6, 2 December 2014, Pages 1049–1058
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Quantitative imaging of inositol distribution in yeast using multi-isotope imaging mass spectrometry (MIMS). Saiardi, A; Guillermier, C; Loss, O; Poczatek, JC; Lechene, C; (2014) Surface and Interface Analysis. Volume 46, Issue S1, 10.1002/sia.5659
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Approaches to increasing analytical throughput of human samples with multi-isotope imaging mass spectrometry. Matthew L. Steinhauser,Christelle Guillermier, Mei Wang and Claude P. Lechene. Surface and Interface Analysis. Volume 46, Issue S1, pages 165-168, November 2014. Article first published online: 11 JUN 2014. DOI: 10.1002/sia.5580
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Quantifying cell division with deuterated water and multi-isotope imaging mass spectrometry (MIMS). Matthew L. Steinhauser, Christelle Guillermier, Mei Wang3 and Claude P. Lechene. Surface and Interface Analysis Volume 46, Issue S1, pages 161–164, November 2014. Article first published online: 6 JUN 2014. DOI: 10.1002/sia.5581
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Quantitative imaging of selenoprotein with multi-isotope imaging mass spectrometry (MIMS). S.S. Tang, C. Guillermier, M. Wang, J. C. Poczatek, N. Suzuki, J. Loscalzo and C. Lechene. Surface and Interface Analysis Volume 46, Issue S1, pages 154–157, November 2014. Article first published online: 7 AUG 2014. DOI: 10.1002/sia.5625
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Detection of immunolabels with multi-isotope imaging mass spectrometry. G. Thiery-Lavenant, C. Guillermier2, M. Wang and C. Lechene. Surface and Interface Analysis Volume 46, Issue S1, pages 147–149, November 2014. Article first published online: 22 JUN 2014. DOI: 10.1002/sia.5596
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Stable isotope imaging of biological samples with high resolution secondary ion mass spectrometry and complementary techniques. H. Jiang, E. Favaro, C.N. Goulbourne, P.D. Rakowska, G.M. Hughes, M.G. Ryadnov, L.G. Fong, S.G. Young, D.J.P. Ferguson, A.L. Harris, C.R.M. Grovenor. Methods 68 (2014) 317–324
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Most Human Proteins Made in Both Nucleus and Cytoplasm Turn Over within Minutes. Sabyasachi Baboo, Bhaskar Bhushan, Haibo Jiang, Chris R. M. Grovenor, Philippe Pierre, Benjamin G. Davis, Peter R. Cook. PLOS ONE, 1 June 2014, Volume 9, Issue 6
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The GPIHBP1–LPL Complex Is Responsible for the Margination of Triglyceride-Rich Lipoproteins in Capillaries. Chris N. Goulbourne, Peter Gin, Angelica Tatar, Chika Nobumori, Andreas Hoenger, Haibo Jiang, Chris R.M. Grovenor, Oludotun Adeyo, Jeffrey D. Esko, Ira J. Goldberg, Karen Reue, Peter, Tontonoz,Andre Bensadoun, Anne P. Beigneux, Stephen G. Young, and Loren G. Fong. Cell Metabolism 19, 849–860, May 6, 2014
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Mycobacterium tuberculosis Exploits Asparagine to Assimilate Nitrogen and Resist Acid Stress during Infection. Gouzy A, Larrouy-Maumus G, Bottai D, Levillain F, Dumas A, Wallach JB, Caire-Brandli I, de Chastellier C, Wu TD, Poincloux R, Brosch R, Guerquin-Kern JL, Schnappinger D, Sório de Carvalho LP, Poquet Y, Neyrolles O. PLoS Pathog. 2014 Feb 20;10(2) 

Nanoscale imaging reveals laterally expanding antimicrobial pores in lipid bilayers. Paulina D. Rakowska, Haibo Jiang, Santanu Ray, Alice Pyne, Baptiste Lamarre, Matthew Carr, Peter J. Judge, Jascindra Ravi, Ulla I. M. Gerling, Beate Koksch, Glenn J. Martyna, Bart W. Hoogenboom, Anthony Watts, Jason Crain, Chris R. M. Grovenor, and Maxim G. Ryadnov. PNAS, May 28, 2013, vol. 110, no. 22
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Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate. Gouzy A, Larrouy-Maumus G, Wu TD, Peixoto A, Levillain F, Lugo-Villarino G, Gerquin-Kern JL, de Carvalho LP, Poquet Y, Neyrolles O. Nat Chem Biol. 2013 Nov;9(11):674-6

Study of Reactive Oxygen or/and Nitrogen Species Binding Processes on E. coli Bacteria with Mass Spectrometry Isotopic Nanoimaging. David Duday, Franck Clement, Elodie Lecoq, Christian Penny, Jean-Nicolas Audinot, Thierry Belmonte, Kinga Kutasi, Henry-Michel Cauchie, Patrick Choquet. Plasma Process. Polym. 2013, DOI: 10.1002/ppap.201200173
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Colocalization of the Ganglioside GM1 and Cholesterol Detected by Secondary Ion Mass Spectrometry. 
 Mónica M. Lozano, Zhao Liu, Eva Sunnick,Andreas Janshoff, Krishna Kumar, and Steven G. Boxer. Journal of the American Chemical Society, 2013, 135, 5620−5630
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Host-compound foraging by intestinal microbiota revealed by single-cell stable isotope probing. David Berry, Bärbel Stecher, Arno Schintlmeistera, Jochen Reicherta, Sandrine Brugiroux Birgit Wild, Wolfgang Wanek, Andreas Richter, Isabella Rauch, Thomas Decker, Alexander Loy, and Michael Wagner. Edited by Ralph R. Isberg, Howard Hughes Medical Institute, Tufts University School of Medicine, Boston, MA, and approved February 6, 2013
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Publication page from the web site of the NRIMS, National Resource for Imaging Mass Spectrometry, Harvard Medical School/MIT/Brigham & Women's Hospital, Cambridge, MA, USA
> View page

Direct chemical evidence for sphingolipid domains in the plasma membranes of fibroblasts.
Jessica F. Frisz, Kaiyan Lou, Haley A. Klitzing, William P. Hanafin, Vladimir Lizunov, Robert L. Wilson, Kevin J. Carpenter, Raehyun Kim, Ian D. Hutcheon, Joshua Zimmerberg, Peter K. Weber, and Mary L. Kraft. PNAS Early Edition 2013
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Identification and localization of nanoparticles in tissues by mass spectrometry.
Jean-Nicolas Audinot, Anastasia Georgantzopoulou, Jean-Pascal Piret, Arno C. Gutleb, David Dowsett, Henri Noel Migeon and Lucien Hoffmann. Surf. Interface Anal. 2013, 45, 230–233
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50nm-Scale Localization of Single Unmodified,Isotopically Enriched, Proteins in Cells.
Anthony Delaune, A. Cabin-Flaman, G. Legent, D. Gibouin, C. Smet-Nocca, F. Lefebvre, A. Benecke, M. Vasse, Camille Ripoll. PLOS ONE, February 2013, Volume 8, Issue 2, e56559
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Unregulated brain iron deposition in transgenic mice overexpressing HMOX1 in the astrocytic compartment.
Wei Song, H.Zukor, S-H Lin, A. Liberman, A. Tavitian, J. Mui, H. Vali, C. Fillebeen, K. Pantopoulos, T-D u, J-L Guerquin Kern, H.M. Schipper. Journal of neurochemistry, 2012, 123, 325-336.
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Mammalian heart renewal by pre-existing cardiomyocytes. Samuel E. Senyo, M. L. Steinhauser, C. L. Pizzimenti, V. K. Yang, L. Cai, M. Wang, T-D Wu, J-L Guerquin-Kern, C. P. Lechene & R. T. Lee. NATURE (05 December 2012) doi:10.1038/nature11682
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Early in vivo changes in calcium ions, oxidative stress markers, and ion channel immunoreactivity following partial injury to the optic nerve. Wells J, Kilburn MR, Shaw JA, Bartlett CA, Harvey AR, Dunlop SA, Fitzgerald M. J Neurosci Res. 2012 Mar;90(3):606-18
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Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia. Duan-Sun Zhang, Valeria Piazza, Benjamin J. Perrin, Agnieszka K. Rzadzinska, J. Collin Poczatek, MeiWang, Haydn M. Prosser, James M. Ervasti, David P. Corey & Claude P. Lechene. NATURE, vol 481, 26 January 2012
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View supplement movies:
> Supplement 1
> Supplement 2
> Supplement 3

Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism. Matthew L. Steinhauser, Andrew P. Bailey, Samuel E. Senyo, Christelle Guillermier, Todd S. Perlstein, Alex P. Gould, Richard T. Lee & Claude P. Lechene. NATURE, vol 481, 26 January 2012
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Retinal Histopathologic Manifestations and Iron-Mediated Melanosome Degradation. Natalie Wolkow, PhD; Ying Song, MD; Ting-Di Wu, PhD; Jiang Qian, MD, PhD; Jean-Luc Guerquin-Kern, PhD; Joshua L. Dunaief, MD, PhD. Arch Ophthalmol. 2011;129(11):1466-1474
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Combed single DNA molecules imaged by secondary ion mass spectrometry. Armelle Cabin-Flaman, Anne-Franc-oise Monnier, Yannick Coffinier, Jean-Nicolas Audinot, David Gibouin, Tom Wirtz, Rabah Boukherroub, Henri-No€el Migeon, Aaron Bensimon, Laurent Jannière, Camille Ripoll, and Vic Norris. Analytical Chemistry (2011) 83,6940-6947. 
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Aceruloplasminemia: Retinal Histopathologic Manifestations and Iron-Mediated Melanosome Degradation.
Natalie Wolkow, Ying Song, Ting-Di Wu, Jiang Qian, Jean-Luc Guerquin-Kern, Joshua L. Dunaief. ARCH OPHTHALMOL, VOL 129 (NO. 11), NOV 2011.
 > Download (1.2MB)

HO-1-mediated macroautophagy: a mechanism for unregulated iron deposition in aging and degenerating neural tissues. Hillel Zukor, W. Song, A. Liberman, J. Mui, H. Vali, C. Fillebeen, K. Pantopoulos, T-D Xu, J-L Guerquin-Kern, H.M. Schipper. Journal of neurochemistry, 2009, 109, 776-791.
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Advances in Imaging Secondary Ion Mass Spectrometry for Biological Samples. Steven G. Boxer, Mary L. Kraft, and Peter K.Weber. Annual Review of Biophysics 2009. 38:53–74.
> Download pdf (767 KB)

Direct chemical evidence for sphingolipid domains in the plasma membranes of fibroblasts. Jessica F. Frisz, K. Lou, H. A. Klitzing, W. P. Hanafin, V. Lizunov, R. L. Wilson, K. J. Carpenter, R. Kim, I. D. Hutcheon, J. Zimmerberg, P. K. Weber, Mary L. Kraft.
> Download pdf (7.4 MB)

Morphological and chemical studies of pathological human and mice brain at the subcellular level: correlation between light, electron, and NanoSIMS microscopies. Carmen Quintana, Ting-Di Wu, Benoit Delatour, Marc Dhenain, Jean Luc Guerquin-Kern, Alain Croisy. Microscopy Research and Technique 70:281–295 (2007)
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Subcellular imaging of isotopically labeled carbon compounds in a biological sample by ion microprobe (NanoSIMS). Peta L. Clode, Richard A. Stern, Alan T. Marshall. Microscopy Research and Technique, 70: 220-229 (2007)
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High-resolution quantitative imaging of mammalian and bacterial cells using stable isotope mass spectrometry. Claude Lechene et al. , Journal of Biology 2006, 5:20. 30 pages
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Phase separation of lipid membranes analyzed with high-resolution Secondary Ion Mass Spectrometry.
Mary L. Kraft et al., SCIENCE, 29 sept 2006, vol.313
> Download pdf (1.1MB)

Sub-cellular localisation of a 15N-labelled peptide vector using NanoSIMS imaging. Winfried Romer , Ting-Di Wu , Patricia Duchambon , Mohamed Amessou , Daniele Carrez , Ludger Johannes , Jean-Luc Guerquin-Kern, Applied Surface Science 252 pp 6925–6930 (2006)
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Study of the localization of iron, ferritin and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level.
C. Quintana, S. Bellefqih, J.Y. Laval, J.L. Guerquin-Kern, T.D. Wu, J. Avila, I.Ferrer, R. Arranz, C. Patino. Journal of Structural Biology 153, 2006
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Direct NanoSIMS imaging of diffusible elements in surfaced block of cryo-processes biological samples.
P. Hallegot, J-N. Audinot, H-N. Migeon, SIMS XV Conference Proceedings, 2005

Supported membrane composition analysis by SIMS with high lateral resolution. Carine Galli Marxer, Mary L. Kraft, Peter K. Weber, Ian Hutcheon, Steven G. Boxer. Biophysical Journal, volume 88, April 2005 p. 2695-2975

Progress in analytical imaging of the cell by secondary ion mass spectrometry (SIMS microscopy). Jean-Luc Guerquin-Kern, Ting-Di Wu, Carmen Quintana and Alain Croisy. Biochimica et Biophysica Acta 1724 (2005) 228 – 238

Measurement of carbon and nitrogen stable isotope ratios in cultured cells. Peteranderl, R. and C. Lechene. Journal of the American Society for Mass Spectrometry. 15: 478–485, 2004

Transport of 13C-oleate in adipocytes measured using multi imaging mass spectrometry. Alan M. Kleinfeld, J. Patrick Kampf, and Claude Lechene. Journal of the American Society for Mass Spectrometry, July 2004

Physiological application of the NanoSIMS 50 ion microscope: localization at subcellular level of 15N labelling in Arabidopsis thaliana. N. Grignon, J. J. Vidmar, F. Hillion, B. Jaillard, Poster for SIMS XII, Brussels, sept. 99.

Subcellular localization of isotopes and labelled molecules by SIMS. E. Hindié, Proceedings of SIMS XI, p.113, Orlando 1997

Improvements in biomedical imaging by SIMS (IMS3f, 4f and NanoSIMS). E. Larras-Regard and M-C. Mony, Proceedings of SIMS XI, p. 119, Orlando 1997

We also recommend a book in which Dr. Nicole Grignon details in one chapter her long experience on bulk biological sample preparation for SIMS analysis (plants): Electron Microscopy Methods and Protocols, 2nd edition. Edited by John Kuo. Series: Methods in Molecular Biology. Humana Press. 

... and the Chapter XXI of "Handbook of Cryopreparation Methods for Electron Microscopy": Cryo-Preparation Procedures for Elemental Imaging by SIMS and EFTEM, by C. Bordat and J-L. Guerquin-Kern. Ed. A Cavalier, D. Spehner, B. M. Humbel. CRC Press (July 2008).

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Nuclear Glass Durability: New Insight into Alteration Layer Properties.Stéphane Gin, Claire Guittonneau, Nicole Godon, Delphine Neff, Diane Rebiscoul, Martiane Cabié, and Smail Mostefaoui. J. Phys. Chem. C, 2011, 115 (38), pp 18696–18706.
> Download pdf (6.4 MB)

Cold crucible induction melter studies for making glass ceramic waste forms: A feasibility assessment. Jarrod Crum , Vince Maio, John McCloy, Clark Scott, Brian Riley, Brad Benefiel, John Vienna, Kip Archibald, Carmen Rodriguez, Veronica Rutledge, Zihua Zhu, Joe Ryan, Matthew Olszta. Journal of Nuclear Materials. Volume 444, Issues 1–3, January 2014, Pages 481–492
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Mitigating Voltage Fade in Cathode Materials by Improving the Atomic Level Uniformity of Elemental Distribution. Jianming Zheng, Meng Gu, Arda Genc, Jie Xiao, Pinghong Xu, Xilin Chen, Zihua Zhu, Wenbo Zhao, Lee Pullan, Chongmin Wang, and Ji-Guang Zhang. Nano Lett., 2014, 14 (5), pp 2628–2635 DOI: 10.1021/nl500486y
> Download pdf (1.9MB)

NanoSIMS imaging alteration layers of a leached SON68 glass via a FIB-made wedged crater. Yi-Chung Wang, Daniel K. Schreiber, James J. Neeway, Suntharampillai Thevuthasan, James E. Evans, Joseph V. Ryan, Zihua Zhu and Wei David Wei. Surface and Interface Analysis, Volume 46, Issue S1, pages 233–237, November 2014
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High-temperature crack growth in a Ni-base superalloy during sustained load. Magnus Hörnqvist, Leif Viskari, Katie L.Moore, Krystyna Stiller. Materials Science&EngineeringA 609 (2014) 131–140
> Download pdf (4.33 MB)

An investigation of the oxidation behaviour of zirconium alloys using isotopic tracers and high resolution SIMS. Sean S. Yardley, Katie L. Moore, Na Ni, Jang Fei Wei, Stuart Lyon, Michael Preuss, Sergio Lozano-Perez, Chris R.M. Grovenor. Journal of Nuclear Materials 443 (2013) 436–443
> Download pdf (2.38 MB)

Examinations of Oxidation and Sulfidation of Grain Boundaries in Alloy 600 Exposed to Simulated Pressurized Water Reactor Primary Water. D.K. Schreiber, M.J. Olszta, D.W. Saxey, K. Kruska, K.L. Moore, S. Lozano-Perez and S.M. Bruemmer. Microsc. Microanal. 19, 676–687, 2013
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Multi-Scale Correlative Microscopy Investigation of Both Structure and Chemistry of Deformation Twin Bundles in Fe–Mn–C Steel. Ross K.W. Marceau, Ivan Gutierrez-Urrutia, Michael Herbig, Katie L. Moore, Sergio Lozano-Perez, and Dierk Raabe. Microsc. Microanal. 2013, Page 1 of 5. doi:10.1017/S1431927613013494 
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Codoping titanium dioxide nanowires with tungsten and carbon for enhanced photoelectrochemical performance. In Sun Cho, Chi Hwan Lee, Yunzhe Feng, Manca Logar, Pratap M. Rao, Lili Cai, Dong Rip Kim, Robert Sinclair & Xiaolin Zheng. Nature Communications, 16 Apr 2013, DOI:10.1038/ncomms2729
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Redistribution and Effect of Various Elements on the Morphology of Primary Graphite in Cast Iron. J. Lacaze, N. Valle, K. Theuwissen, J. Sertucha, B. El Adib and L. Laffont. Hindawi Publishing Corporation
Advances in Materials Science and Engineering. Volume 2013, Article ID 638451, 9 pages
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Interaction of micro-discharges in heptane with metallic multi-layers. A. Hamdan, J.-N. Audinot, C. Noel, F. Kosior, G. Henrion, T. Belmonte. Applied Surface Science 274 (2013) 378– 391
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A SIMS and TEM investigation of the microstructure of wear-resistant ductile cast iron. N. Valle, M. Martinez Celis, J. Lacaze, I. O. Thorbjornsson, B. Johannesson and J. T. Thorgrimsson. Surf. Interface Anal. 2013, 45, 441–444
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Quantitative grain boundary analysis of bulk samples by SIMS. F. Christien, C. Downing, K. L. Moore C. R. M. Grovenor. Surf, Interface Anal. 2013, 45, 305–308
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Nanometric Scale Investigation of Phase Transformations in Advanced Steels for Automotive Application. José Drillet, Nathalie Valle and Thierry Iung. The Minerals, Metals & Materials Society and ASM International 2012. DOI: 10.1007/s11661-012-1218-1
> Download pdf (1.09 MB)

Composition of nanoparticles in optical fibers by Secondary Ion Mass Spectrometry. Wilfried Blanc, Christelle Guillermier and Bernard Dussardier. November 2012 / Vol. 2, No. 11 / OPTICAL MATERIALS EXPRESS 1504.
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Segregation of B, P, and C in the Ni-Based Superalloy, Inconel 718. Talukder Alam, Peter J. Felfer, Mahesh Chaturvedi, Leigh T. Stephenson, Matthew R. Kilburn, Julie M. Cairney. Metallurgical and Materials Transactions A July 2012, Volume 43, Issue 7, pp 2183-2191.
 > Download pdf (1MB)

Quantification of grain boundary equilibrium segregation by NanoSIMS analysis of bulk samples. F. Christien, C. Downing, K. L. Moore and C. R. M. Grovenor. Surf. Interface Anal. 2012, 44, 377–387
> Download pdf (0.68 MB)

Mechanisms of Oxidation of Fuel Cladding Alloys Revealed by High Resolution APT, TEM and SIMS Analysis. Chris R. M. Grovenor, Na Ni, Daniel Hudson, Sean S. Yardley, Katie L. Moore, George D. W. Smith, Sergio LozanoPerez and John M. Sykes. MRS Proceedings, Volume 1383, 2012
> Download pdf (1.77 MB)

How the crystallography and nanoscale chemistry of the metal/oxide interface develops during the aqueous oxidation of zirconium cladding alloys. N. Ni, D. Hudson, J. Wei, P. Wang, S. Lozano-Perez, G.D.W. Smith, J.M. Sykes, S.S. Yardley, K.L. Moore, S. Lyon, R. Cottis, M. Preuss, C.R.M. Grovenor. Acta Materialia 60 (2012) 7132–7149
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Spinel-Layered Core-Shell Cathode Materials for Li-Ion Batteries. Cho, Y., Lee, S., Lee, Y., Hong, T. and Cho, J. (2011), Adv. Energy Mater., 1: 821–828. doi: 10.1002/aenm.201100239.
> Download pdf (1MB)

Nano-SIMS investigation of boron distribution in steels. N. Valle, J. Drillet, A. Picc and H.-N. Migeon. Surf. Interface Anal. 2011, 43, 573–575.
> Download pdf (171KB)

Wear property of Ductile Iron Locally Reinforced with Cr-Containing Steel Inserts. Mayerling Martinez Celis, Nathalie Valle, Jacques Lacaze, Ingólfur Thorbjornsson, Birgir Johannesson, JonThor Thorgrimsson, Bojan Podgornik, Joze Vizintin. Key Engineering Materials Vol. 457 (2011) pp 441-446.
> Download pdf (3.97MB)

Microstructure of as cast reinforced ductile iron. M. Martinez Celis, N. Valle, J. Lacaze, I. O. Thorbjornsson, B. Johannesson and J. T. Thorgrimsson. International Journal of Cast Metals Research 2011 VOL 24 NO 2.
> Download pdf (721KB) 

Structural Changes Evidenced by Rheology in PPgMA Nanocomposites During Oxidative Ageing
F. Fordiani, T. Aubry, Y. Grohens Journal of Applied Polymer Science, Vol. 114, 4011–4019 (2009)
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Multi-scale characterization of stress corrosion cracking of cold-worked stainless steels and the influence of Cr content. S. Lozano-Perez, T. Yamada, T. Terachi , M. Schroder , C.A. English , G.D.W. Smith , C.R.M. Grovenor , B.L. Eyre. Acta Materialia 57 (2009) 5361–5381.
> Download pdf (2.02MB)

Application of SIMS nano-analysis to the development of new metallurgical solutions. N. Valle, J. Drillet, A. Perlade, H.-N. Migeon. Applied Surface Science 255 (2008) 1569–1571.
> Download pdf (396KB)

Using NanoSIMS to map trace elements in stainless steels from nuclear reactors. S. Lozano-Perez, M. Schroeder, T. Yamada, T. Terachi, C.A. English and C.R.M. Grovenor. Applied Surface Science (2008).
> Download pdf (629KB)

High-resolution imaging of complex crack chemistry in reactor steels by NanoSIMS. S. Lozano-Perez, M.R. Kilburn, T. Yamada, T. Terachi, C.A. English and C.R.M. Grovenor. Journal of Nuclear Materials, Available online 19 August 2007
> Download pdf (1.4MB)

NanoSIMS analysis of trace element segregation during the Al-Si eutectic reaction. Christian J. Simensen, Oyvind Nielsen, Francois Hillion, Jorunn Voje, Metallurgical and Materials Transactions A, 2007 , DOI: 10.1007/s11661-007-9165-y
> Download pdf (383kB)

Study of the carbon distribution in multi-phase steels using the NanoSIMS 50. N. Valle , J. Drillet, O. Bouaziz, H.-N. Migeon. Applied Surface Science 252 (2006) 7051–7053.
> Download pdf (219KB)

High-Temperature oxidation of a Cu-Ni based Cermet: kinetic and microstructural study. F. Rioult, M. Pijolat, F. Valdivieso, M.A. Prin-Lamaze, Journal of American Ceramic society, 89 [3] 996-1005 (2006)

Simultaneous multidopant investigation of rare-earth-doped optical fibers by an ion microprobe. F. Sidiroglou, S.T. Huntington, A. Roberts, R. Stern, I.R.Fletcher, G.W. Baxter. Optics Letters, vol31, N°22, november 15, 2006

Three-dimensional investigation of microstructure of multiphase steels. Nathalie Valle, J. Drillet, O. Bouaziz, H-N. Migeon, poster for SIMS Europe 2006

Chemical interactions in Ti doped MgB2 superconducting bulk samples and wires. S Haigh, P Kovac, TA Prikhna, Ya M Savchuk, M R Kilburn, C Salter, J Hutchison and C Grovenor. Supercond. Sci. Technol. 18 (2005), pp 1190-1196
> Download pdf (1.32 MB)

Multitechnique characterization of thin films of immiscible polymer systems: PS-b-PMMA diblock copolymers and PS-PMMA symmetric blends. L. Kailas, B. Nysten, J-N. Audinot, H-N. Migeon, P. Bertrand. Surface and Interface Analysis 2005; 37: 435-443.

Bainite characterization: carbon concentration measurements using the NanoSIMS 50. Nathalie Valle, J. Drillet, O. Bouaziz, H-N. Migeon, poster for SIMS Europe 2004.


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Geology and Environment

Sulphur geodynamic cycle. Takanori Kagoshima, Yuji Sano, Naoto Takahata, Teruyuki Maruoka, Tobias P. Fischer & Keiko Hattori. Scientific Reports 5, Article number: 8330 (2015) doi:10.1038/srep08330
> Download pdf (922KB)

Slab melting beneath the Cascade Arc driven by dehydration of altered oceanic peridotite. K. J. Walowski, P. J. Wallace, E. H. Hauri, I. Wada & M. A. Clynne. Nature Geoscience 8, 404–408 (2015) doi:10.1038/ngeo2417
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High-Mg Adakite and Low-Ca Boninite from a Bonin Fore-arc Seamount: Implications for the Reaction between Slab Melts and Depleted Mantle. Yi-Bing Li, Jun-Ichi Kimura, Shiki Machida, Teruaki Ishii, Akira Ishiwatari, Shigenori Maruyama, Hua-Ning Qiu, Tsuyoshi Ishikawa, Yasuhiro Kato, Satoru Haraguchi, Naoto Takahata, Yuka Hirahara and Takashi Miyazaki. Journal of Petrology, volume 54, number 6, pages 1149-1175, 2013. doi:10.1093/petrology/egt008
> Download pdf (1.70 MB)

NanoSIMS: Technical Aspects and Applications in Cosmochemistry and Biological Geochemistry.
Peter Hoppe, Stephanie Cohen, Anders Meibom. Geostandards and Geoanalytical Research, June, 2013.
> Download pdf (5.363 MB)

EMP and SIMS studies on Mn/Ca and Fe/Ca systematics in benthic foraminifera from the Peruvian OMZ: a contribution to the identification of potential redox proxies and the impact of cleaning protocols. Glock N., Eisenhauer A., Liebetrau V., Wiedenbeck M., Hensen C. & Nehrke G., 2012. Biogeosciences 9:341-359.
> Download pdf (809KB) 

Precise micrometre-sized Pb-Pb and U-Pb dating with NanoSIMS. Wei Yang, Yang-Ting Lin, Jian-Chao Zhang, Jia-Long Hao, Wen-Jie Shen and Sen Hu. The Royal Society of Chemistry 2012. DOI: 10.1039/c2ja10303f
> Download pdf (930 KB)

Earliest microbially-mediated pyrite oxidation in ~3.4 billion-year-old sediments. D. Wacey, M. Saunders, M.D. Brasier, M.R. Kilburn. EPSL 301 (2011) 293-402.
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Microfossils of sulphur-metabolizing cells in 3.4-billion-year-old rocks of Western Australia.
David Wacey, Matt R. Kilburn, Martin Saunders, John Cliff & Martin D. Brasier, Nature Geoscience, Published online 21 August 2011 doi:10.1038/ngeo1238
> Download pdf (1MB)

Microbialite taphonomy and biogenicity: new insights from NanoSIMS. David Wacey, D. Gleeson, Matt R. Kilburn. Geobiology (2010) DOI: 10.1111/j.1472-4669.2010.00251.x
> Download pdf (3.83 MB)

Diversity in the Archean Biosphere: New Insights from NanoSIMS.
Dorothy Z.Oehler, Francois Robert, Malcolm R.Walter, Kenichiro Sugitani, Anders Meibom, Smail Mostefaoui, and Everett K.Gibson. Astrobiology vol 10, number 4, 2010, p. 413 - 424
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Uncloaking invisible gold: Use of NanoSIMS to evaluate gold, trace elements, and sulfur isotopes in pyrite from carlin-type gold deposits.
Shaun L.L. Barker, Kenneth A. Hickey, Jean S. Cline, Gregory M. Dipple, Matt R. Kilburn, Jeremy R. Vaughan and Anthony A. Longo. Economic Geology, v. 104, no. 7, (Nov 2009) 897-904
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Geobiological investigations using secondary ion mass spectrometry: microanalysis of extant and paleo-microbial processes. V. J. Orphan and C. H. House. Geobiology (2009), 7, 360–372.
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Evidence for microbial life in synsedimentary cavities from 2.75 Ga terrestrial environments. Birger Rasmussen, Tim S. Blake, Ian R. Fletcher, and Matt R. Kilburn. GEOLOGY vol37 nb5 , May 2009.
> Download pdf (479KB)

Reassessing the first appearance of eukaryotes and cyanobacteria. Birger Rasmussen, Ian R. Fletcher, Jochen J. Brocks & Matt R. Kilburn. NATURE, Vol 455, 23 Oct. 2008, p. 1101-1105
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NanoSIMS micron-scale in situ measurement of 13C/12C in early precambrian organic matter, with permil precision.
Ian R. Fletcher, M. R. Kilburn, B. Rasmussen. Int. J. Mass Spectrom, 2008
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Extracellular proteins limit the dispersal of biogenic nanoparticles. John W. Moreau, P. K. Weber, M.C.Martin, B.Gilbert, I.D.Hutcheon, J.F.Banfield. SCIENCE, Vol. 316, 15 june 2007, p.1600-1604.

Elemental distribution in cephalopod statoliths: NanoSIMS provides new insights into nano-scale structure. Karsten Zumholz, Thor Hansteen, F. Hillion, F. Horreard, U. Piatkowski, Rev. Fish Biol Fisheries, accepted 30nov 2006

Colloid transport of Plutonium in the far-field of the Mayak production association, Russia. Alexander P. Novikov, Stepan N. Kalmykov, Satoshi Utsunomiya, Rodney C. Ewing, François Horréard, Alex Merkulov, Sue B. Clark, Vladimir V. Tkachev, Boris F. Myasoedov. SCIENCE, Vol 314, 27 october 2006, p. 638-641

The application of HRTEM techniques and NanoSIMS to chemically and isotopically characterize Geobacter sulfurreducens surfaces. Fayek, M., S. Utsunomiya, S. M. Pfiffner, D. C. White, L. R. Riciputi, R. C. Ewing, L. M. Anovitz, and F. J. Stadermann. Canadian Mineralogist 43:1631-1641 (2005).
> Download pdf (811KB)

Nano-SIMS Analysis of Mg, Sr, Ba and U in natural calcium carbonate. Yuji Sano, K. Shirai, N. takahata, T. Hirata, N.C.Sturchio. Analytical Sciences, september 2005, vol.21, p1091-1097

Ion Microprobe (NanoSIMS 50) Pb-isotope geochronology at < 5µm scale. Richard A. Stern, Ian Fletcher, Birger Rasmussen, Neal J. McNaughton, Brendan Griffin. International Journal of Mass Spectrometry, May 25, 2005.

Study of the mechanism of diatom cell division by means of 29Si isotope tracing. J-N. Audinot, C. Guignard, H-N. Migeon, L. Hoffmann. SIMS XV proceedings, 2005.


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New chronological constraints for Cryogenian to Cambrian rocks in the Three Gorges, Weng'an and Chengjiang areas, South China. Yoshihiro Okada, Yusuke Sawaki, Tsuyoshi Komiya, Takafumi Hirata, Naoto Takahata, Yuji Sano, Jian Han, Shigenori Maruyama. Gondwana Research 25 (2014) 1027–1044
> Download pdf (5.32 MB)

Precise micrometre-sized Pb-Pb and U-Pb dating with NanoSIMS. Wei Yang, Yang-Ting Lin, Jian-Chao Zhang, Jia-Long Hao, Wen-Jie Shen and Sen Hu. The Royal Society of Chemistry 2012. DOI: 10.1039/c2ja10303f
> Download pdf (0.93 MB)

Ion microprobe U–Pb dating of zircon with a 15 micrometer spatial resolution using NanoSIMS. Naoto Takahata, Yukiyasu Tsutsumi, Yuji Sano. Gondwana Research 14 (2008) 587–596. doi:10.1016/
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Internal structures and U–Pb ages of zircons from a tuff layer in the Meishucunian formation, Yunnan Province, South China. Yusuke Sawaki, Manabu Nishizawa, Takeshi Suo, Tsuyoshi Komiya, Takafumi Hirata, Naoto Takahata, Yuji Sano, Jian Han, Yoshiaki Kon, Shigenori Maruyama. Gondwana Research 14 (2008) 148–158. doi:10.1016/
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Ion microprobe U-Pb dating of monazite with about five micrometer spatial resolution. Yuji Sano,Naoto Takahata, Yukiyasu Tsutsumi and Tomoharu Miyamoto. Geochemical Journal, Vol. 40, pp. 597 to 608, 2006
> Download pdf (1.80 MB) 

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Planetary Sciences


Carbon content and degassing history of the lunar volcanic glasses. Diane T. Wetzel, Erik H. Hauri, Alberto E. Saal & Malcolm J. Rutherford. Nature Geoscience 8, 755–758 (2015)
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The deuterium/hydrogen distribution in chondritic organic matter attests to early ionizing irradiation. Boris Laurent, Mathieu Roskosz, Laurent Remust, Francois Robert, Hugues Leroux, Herve Vezin, Christophe Depecker, Nicolas Nuns & Jean-Marc Lefebvre. Nature communications_13 Oct 2015
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Comprehensive study of carbon and oxygen isotopic compositions, trace element abundances, and cathodoluminescence intensities of calcite in the Murchison CM chondrite. Wataru Fujiya, Naoji Sugiura, Yves Marrocchi, Naoto Takahata, Peter Hoppe, Kotaro Shirai , Yuji Sano, Hajime Hiyagon. Geochimica et Cosmochimica Acta 161 (2015) 101–117
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Nickeliferous pyrite tracks pervasive hydrothermal alteration in Martian regolith breccia: A study in NWA 7533. Jean-Pierre Lorand, Roger H. Hewins, Laurent Remust, Brigitte Zanda, Sylvain Pont, Hugues Leroux, Maya Marinova, Damien Jacob, Munir Humayun, Alexander Nemchin, Marion Grange, Allen Kennedy and Christa Göpel. Meteoritics & Planetary Science, Volume 50, Issue 12, December 2015, Pages: 2099–2120.
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Fluid-induced organic synthesis in the solar nebula recorded in extraterrestrial dust from meteorites. Christian Vollmer, Demie Kepaptsoglou, Jan Leitner, Henner Busemann, Nicole H. Spring, Quentin M. Ramasse, Peter Hoppe, and Larry R. Nittler. PNAS, October 28, 2014, vol. 111, no. 43
> Download pdf (1.4 MB)

The negligible chondritic contribution in the lunar soils water. Alice Stephant and François Robert. PNAS, October 21, 2014. Vol.111, No 42
> Download pdf (0.8 MB)

Ion microprobe Al–Mg dating of single plagioclase grains in an Efremovka chondrule. Yuji Sano, Moi Takada, Naoto Takahata, Wataru Fujiya and Naoji Sugiura. Geochemical Journal, Vol. 48, pp. 133 to 144, 2014
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The abundance, distribution, and isotopic composition of hydrogen in the Moon as revealed by basaltic lunar samples: Implications for the volatile inventory of the Moon. Romain Tartese, Mahesh Anand , Jessica J. Barnes, Natalie A. Starkey, Ian A. Franchi, Yuji Sano. Geochimica et Cosmochimica Acta. 12/2013
> Download pdf (2.3 MB)
Origin and Evolution of Prebiotic Organic Matter As Inferred from the Tagish Lake Meteorite. Christopher D. K. Herd, Alexandra Blinova, Danielle N. Simkus, Yongsong Huang, Rafael Tarozo, Conel M. O’D. Alexander, Frank Gyngard, Larry R. Nittler, George D. Cody, Marilyn L. Fogel, Yoko Kebukawa, A. L. David Kilcoyne, Robert W. Hilts, Greg F. Slater, Daniel P. Glavin, Jason P. Dworkin, Michael P. Callahan, Jamie E. Elsila, Bradley T. De Gregorio, Rhonda M. Stroud . Science 10 June 2011: vol. 332 no. 6035 pp. 1304-1307
> Download pdf (1.3 MB)

Evidence for the extraterrestrial origin of a natural quasicrystal. Luca Bindi, John M. Eiler, Yunbin Guan, Lincoln S. Hollister, Glenn MacPherson, Paul J. Steinhardt and Nan Yao. PNAS anuary 31, 2012 vol. 109
> Download pdf (1.1 MB)
Two-stage partial melting and contrasting cooling history within the Higher Himalayan Crystalline Sequence in the far-eastern Nepal Himalaya. Takeshi Imayama, Toru Takeshita, Keewook Yi, Deung-Lyong Cho, Kouki Kitajima, Yukiyasu Tsutsumi, Masahiro Kayama, Hirotsugu Nishido, Tasuku Okumura, Koshi Yagi, Tetsumaru Itaya, Yuji Sano. Lithos 134-135 (2012) 1–22

A NanoSIMS and Raman spectroscopic comparison of interplanetary dust particles from comet Grigg-Skjellerup and non-Grigg Skjellerup collections . Jemma DAVIDSON, Henner BUSEMANN and Ian A. FRANCHI. Meteoritics & Planetary Science 47, Nr 11, 1748–1771 (2012)
> Download pdf (0.6 MB)

Organic Globules in the Tagish Lake Meteorite: Remnants of the Protosolar Disk. Keiko Nakamura-Messenger, Scott Messenger, Lindsay P. Keller, Simon J. Clemett, and Michael E. Zolensky . Science 1 December 2006: 1439-1442.
> Download pdf (0.8 MB)

An Astronomical 2175 Å Feature in Interplanetary Dust Particles. John Bradley, Zu Rong Dai, Rolf Erni, Nigel Browning, Giles Graham, Peter Weber, Julie Smith, Ian Hutcheon, Hope Ishii, Sasa Bajt, Christine Floss, Frank Stadermann, and Scott Sandford . Science 14 January 2005: 244-247.
> Download pdf (0.2 MB)

Reactive ammonia in the solar protoplanetary disk and the origin of Earth’s nitrogen. Dennis Harries, Peter Hoppe & Falko Langenhorst. Nature Geoscience 8, 97–101 (2015) doi:10.1038/ngeo2339
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Unique large diamonds in a ureilite from Almahata Sitta 2008 TC3 asteroid. Masaaki Miyahara, Eiji Ohtani, Ahmed El Goresy, Yangting Lin, Lu Feng, Jian-Chao Zhang, Philippe Gillet, Toshiro Nagase, Jun Muto, Masahiko Nishijima Geochimica et Cosmochimica Acta. Volume 163, 15 August 2015, Pages 14–26
> Download pdf (1.7MB)

Measurements of water content and D/H ratio in apatite and silicate glasses using a NanoSIMS 50L. Sen Hu, Yangting Lin, Jianchao Zhang, Jialong Hao, Wei Yang and Liwei Deng. J. Anal. At. Spectrom., 2015,30, 967-978
> Download pdf (754KB)

NanoSIMS analysis of organic carbon from the Tissint Martian meteorite: Evidence for the past existence of subsurface organic-bearing fluids on Mars. Yangting Lin, Ahmed El Goresy, Sen Hu, Jianchao Zhang, Philippe Gillet, Yuchen Xu, Jialong Hao, Masaaki Miyahara, Ziyuan Ouyang, Eiji Ohtani, Lin Xu, Wei Yang, Lu Feng, Xuchao Zhao, Jing Yang and Shin Ozawa. Meteoritics & Planetary Science. Volume 49, Issue 12, pages 2201–2218, December 2014
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Presolar grains in the CM2 chondrite Sutter's Mill. Xuchao Zhao, Yangting Lin, Qing-Zhu Yin, Jianchao Zhang, Jialong Hao, Michael Zolensky and Peter Jenniskens. Meteoritics & Planetary Science. Volume 49, Issue 11, pages 2038–2046, November 2014
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Improved precision and spatial resolution of sulfur isotope analysis using NanoSIMS. Jianchao Zhang, Yangting Lin, Wei Yang, Wenjie Shen, Jialong Hao, Sen Hu and MingJian Cao. J. Anal. At. Spectrom., 2014, 29, 1934-1943
> Download pdf (2.3MB)
Sintering nano-crystalline calcite: a new method of synthesizing homogeneous reference materials for SIMS analysis. Yangting Lin, Lu Feng, Jialong Hao, Yu Liu, Sen Hu, Jianchao Zhang and Wei Yang. J. Anal. At. Spectrom., 2014,29, 1686-1691
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Presolar Graphitic Carbon Spherules: Rocks from Stars. T. Kevin Croat, Thomas J, Bernatwicz, Tyrone L. Daulton. DOI:10.21113/gselements.10.6.441, Elements, Vol 10 , December 2014
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NanoSIMS, TEM, and XANES studies of a Unique Presolar Supernova Graphite Grain.
Evan Groopman, Larry R. Nittler, Thomas Bernatowicz, Ernst Zinner. The Astrophysical Journal (2014) 790, 9
> Download pdf (4MB)

H, C, and N isotopic compositions of Hayabusa category 3 organic samples. Motoo Ito, Masayuki Uesugi, Hiroshi Naraoka, Hikaru Yabuta, Fumio Kitajima, Hajime Mita, Yoshinori Takano, Yuzuru Karouji, Toru Yada, Yukihiro Ishibashi, Tatsuaki Okada and Masanao Abe. Ito et al. Earth, Planets and Space 2014, 66:102. doi:10.1186/1880-5981-66-102
> Download pdf (3.07 MB)

Evidence for interstellar origin of seven dust particles collected by the Stardust spacecraft. Andrew J. Westphal et al. SCIENCE, 15 August 2014, Vol 345, Issue 6198
> Download pdf (1.78 MB)

Determination of the nitrogen abundance in organic materials by NanoSIMS quantitative imaging. Aurélien Thomen, François Robert and Laurent Remusat. J. Anal. At. Spectrom., 2014, 29, 512. DOI: 10.1039/c3ja50313e
> Download pdf (0.84 MB) 

Sequential analysis of carbonaceous materials in Hayabusa-returned samples for the determination of their origin. Masayuki Uesugi, Hiroshi Naraoka, Motoo Ito, Hikaru Yabuta, Fumio Kitajima, Yoshinori Takano, Hajime Mita, Ichiro Ohnishi, Yoko Kebukawa, Toru Yada, Yuzuru Karouji, Yukihiro Ishibashi, Takaaki Okada, Masanao Abe. Earth, Planets and Space, December 2014, 66:102
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Isotopic and chemical variation of organic nanoglobules in primitive meteorites. Bradley T. De Gregorio, Rhonda M. Stroud, Larry R. Nittler, Conel M. O'D. Alexander, Nabil D. Bassim, George D. Cody, A. L. David Kilcoyne, Scott A. Sandford, Stefanie N. Milam, Michel Nuevo, Thomas J. Zega. . Meteoritics & Planetary Science, Volume 48, Issue 5, pages 904–928, May 2013
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Multi-element isotopic analyses of presolar graphite grains from Orgueil. Manavi Jadhav, Ernst Zinner, Sachiko Amari, Teruyuki Maruoka, Kuljeet K. Marhas, Roberto Gallino. Geochimica et Cosmochimica Acta, Volume 113, Pages 193–224, 15 July 2013
 > Download pdf (3.1MB)

Mn–Cr ages of dolomites in CI chondrites and the Tagish Lake ungrouped carbonaceous chondrite. Wataru Fujiya, Naoji Sugiura, Yuji Sano, Hajime Hiyagon. Earth and Planetary Science Letters 362 (2013) 130–142.
> Download pdf (1.36 MB)

The abundance, distribution, and isotopic composition of Hydrogen in the Moon as revealed by basaltic lunar samples: Implications for the volatile inventory of the Moon. Romain Tartèse, Mahesh Anand, Jessica J. Barnes, Natalie A. Starkey, Ian A. Franchi, Yuji Sano. Geochimica et Cosmochimica Acta 122 (2013) 58–74.
> Download pdf (2.31 MB)

Experimental evidence of fast transport of trace elements in planetary basaltic crusts by high temperature metamorphism. A. Yamaguchi, T.Mikouchi, M.Ito, N.Shirai, J.A.Barrat, S.Messenger, M.Ebihara. Earth and Planetary Science Letters 368 (2013) 101–109
> Download pdf (2.12 MB) 

Strardust Investigation into the CR Chondrite Grove Mountain 021710. Xuchao Zhao, Christine Floss, Yangting Lin and Maitrayee Bose. The Astrophysical Journal, 769:49 (16pp), 2013 May
> Download pdf (2.44 MB)

A Precise 53MN-53CR Age of Sphalerites from the Primitive EH3 Chondrite Sahara 97158. M. Trieloff, J.-C. Storck, S. Mostefaoui, A. El Goresy, J. Hopp, T. Ludwig, R. Altherr. Institute of Geosciences, University of Heidelberg, Im Neuenheimer Feld 234-236, D-69120 Heidelberg, Germany. Abstract.
> Download pdf (125 KB)

Hydrogen Isotopes in Lunar Volcanic Glasses and Melt Inclusions Reveal a Carbonaceous Chondrite Heritage. Alberto E. Saal, Erik H. Hauri, James A. Van Orman, Malcolm J. Rutherford. Science, April 25, 2013.
> Download pdf (1.068 MB)

The Abundance of Presolar Grains in Comet 81P/Wild 2. Christine Floss, Frank J. Stadermann, Anton T. Kearsley, Mark J. Burchell, and W. J. Ong. The Astrophysical Journal, 763:140 (11pp), 2013 February
> Download pdf (2.34 MB)

Insight into the silicate and organic reservoirs of the comet forming region.
Natalie A. Starkey, Ian A. Franchi Geochimica et Cosmochimica Acta 105 (2013) 73–91
> Download (1.5MB)

C, N, and O Isotopic Heterogeneities in Low-density Supernova Graphite Grains from Orgueil. Evan Groopman, Thomas Bernatowicz, Ernst Zinner. The Astrophysical Journal Letters, 754, July 2012
> Download pdf (1.2MB)

D-depleted organic matter and graphite in the Abee enstatite chondrite. L. Remusat, J.-N. Rouzaud, E. Charon, C. Le Guillou, Y. Guan, J.M. Eiler. Geochimica et Cosmochimica Acta 96 (2012) 319–335
> Download pdf (1.99 MB)

Evidence for the late formation of hydrous asteroids from young meteoritic carbonates. Wataru Fujiya, Naoji Sugiura, Hideyuki Hotta, Koji Ichimura & Yuji Sano. nature Communications, Published 17 Jan 2012 DOI: 10.1038/ncomms1635
> Download pdf (719KB)

Laboratory technology and cosmochemistry.
Ernst K. Zinner, Frederic Moynier, and Rhonda M. Stroud. PNAS Vol 108 No 48. Nov. 2011
> Download pdf (754KB)

53Mn-53Cr ages of Kaidun carbonates. M. Petitat, Y. Marrochi, K. D. McKeegan, S. Mostefaoui, A. Meibom, M. E. Zolensjy, and M. Gounelle.   Meteoritics & Planetary Science 46, Nr 2, 275–283 (2011)
> Download pdf (345KB)

Extreme oxygen isotope anomaly with a solar origin detected in meteoritic organics. Ko Hashizume, Naoto Takahata, Hiroshi Naraoka and Yuji Sano. Nature Geoscience 4, 165–168 (2011)
> Download pdf (338KB)

High Pre-Eruptive Water Contents Preserved in Lunar Melt Inclusions. Erik H. Hauri, Thomas Weinreich, Alberto E. Saal, Malcolm C. Rutherford & James A. Van Orman. SciencePublished Online May 26 2011
> Download pdf (2.5MB)

Oxygen Isotope Variations at the Margin of a CAI Records Circulation Within the Solar Nebula. Justin I. Simon, Ian D. Hutcheon, Steven B. Simon, Jennifer E. P. Matzel, Erick C. Ramon, Peter K. Weber, Lawrence Grossman, Donald J. DePaolo. Science 331, 1175 (2011). DOI: 10.1126/science.1197970
> Download pdf (1.1 MB)

Automated NanoSIMS Measurements of Spinel Stardust from the Murray Meteorite. Frank Gyngard, Ernst Zinner, Larry R. Nittler, Alain Morgand, Frank J. Stadermann, K. Mairin Hynes. Astrophysical Journal 717 (2010) 107-120
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Neutron-rich chromium isotope anomalies in supernova nanoparticles. N. Dauphas, L. Remusat, J.H. Chen, M. Roskosz, D.A. Papanastassiou, J. Stodolna, Y. Guan, C. Ma and J.M. Eiler. The Astrophysical Journal, 720:1577–1591, 2010. doi:10.1088/0004-637X/720/2/1577
> Download pdf (2.37 MB)

A promising method to obtain more accurate Mg isotope compositional data on presolar silicate particles.
János Kodolányi and Peter Hoppe. 11th Symposium on Nuclei in the Cosmos, NIC XI, Heidelberg, Germany, July 19–23 2010
> Download pdf (460 KB)

Measurements of presolar grains. Peter Hoppe. 11th Symposium on Nuclei in the Cosmos - NIC XI
Heidelberg, Germany. July 19–23 2010
> Download pdf (1.21 MB)

Extreme Deuterium Excesses in Ultracarbonaceous Micrometeorites from Central Antarctic Snow.
J. Duprat, E. Dobrica, C. Engrand, J. Aléon, Y. Marrocchi, S. Mostefaoui, A. Meibom, H. Leroux, J.-N. Rouzaud, M. Gounelle, F. Robert. SCIENCE vol 328, 7 may 2010, p. 742 - 745
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Constraints on the Formation Age of Cometary Material from the NASA Stardust Mission.
J.E.P. Matzel, H.A. Ishii, D. Joswiak, I.D. Hutcheon, J.P. Bradley, D. Brownlee, P.K. Weber, N. Teslich, G. Matrajt, K.D. McKeegan, G.J. MacPherson. Science DOI: 10.1126/science.1184741. Published Online February 25, 2010
> Download pdf (4.8MB)

Isotopic Analysis of Supernova Sic and Si3N4 Grains from the Qingzhen (EH3) Chondrite.
Yangting Lin, Frank Gyngard and Ernst Zinner. The Astrophysical Journal, 709:1157–1173, 2010 February
> Download pdf (1.83 MB)

Pristine extraterrestrial material with unprecedented nitrogen isotopic variation.
Giacomo Briani, M. Gounelle, Y. Marrocchi, S. Mostefaoui, H. Leroux, E. Quirico, A. Meibom. PNAS doi:10.1073/pnas.0900197106
> Download pdf (2.4MB)

An unusual presolar silicon carbide grain from a supernova: implication for the production of silicon-29 in type-II supernovae.
Peter Hoppe, Jan Leitner, Bradley S. Meyer, Lih-Sin The, Maria Lugaro, and Sachiko Amari. The Astrophysical Journal, 691:L20–L23, 2009 January 20
> Download pdf (343kB)

Si isotopic composition of presolar silicate grains from red giant stars and supernovae.
Christian Vollmer, Peter Hoppe and Frank E.Brenker. The Astrophysical Journal, 684:611Y617, 2008 Sep 1
> Download pdf (406kB)

Carbon investigation of two Stardust particles: A TEM, NanoSIMS, and XANES study.
G. MATRAJT, M. ITO, S. WIRICK, S. MESSENGER, D. E. BROWNLEE, D. JOSWIAK, G. FLYNN, S. SANDFORD, C. SNEAD, A. WESTPHAL. Meteoritics & Planetary Science 43, Nr ½, 315-334 (2008)
> Download pdf (1.7MB)

Volatile content of lunar volcanic glasses and the presence of water in the Moon’s interior.
Alberto E.Saal, Erik H.Hauri, Mauro Lo Cascio, James A.Van Orman, Malcolm C.Rutherford & Reid F.Cooper. NATURE, Vol 454, 10 July 2008, p.192-195
> Download pdf (275kB)

NanoSIMS isotopic analysis of small presolar grains: Search for Si3N4 grains from AGB stars and Al and Ti isotopic compositions of rare presolar SiC grains.
Ernst Zinner, Sachiko Amari, Robert Guinness, Cristine Jennings, Aaron F. Mertz, Ann N. Nguyen, Roberto Gallino, Peter Hoppe, Maria Lugaro, Larry R. Nittler, Roy S. Lewis. Geochimica et Cosmochimica Acta 71 (2007) 4786–4813
> Download pdf (1.83 MB)

High spatial resolution ion microprobe measurements refine chronology of carbonate formation in Orgueil. Peter Hoppe, Doug Macdougall and Günter W. Lugmair. Meteoritics & Planetary Science 42, Nr 7/8, 1309–1320 (2007)

Nitrogen and carbon isotopic composition of the sun inferred from a high-temperature solar nebular condensate. Anders Meibom, A.N. Krot, F. Robert, S. Mostefaoui, S.S. Russell, M.I. Petaev, M. Gounelle. The Astrophysical Journal, 656: L33-L36, 2007 Feb. 10.

Isotopic compositions of cometary matter returned by Stardust. Kevin D. McKeegan et al. SCIENCE vol 314, 15dec 2006, p. 1724- 1728

Interstellar chemistry recorded in organic matter from primitive meteorites. Henner Busemann, Andrea F. Young, ConelM.O'D. Alexander, Peter Hoppe, Sujoy Mukhopadhyay, Larry R. Nittler. SCIENCE, Vol. 312, 5 May 2006, p. 727-730

Supernova olivine from cosmetary dust. Scott Messenger, Lindsay.P. Keller, Dante S. Lauretta. SCIENCE, Vol. 309, 29 July 2005, p.737-741

Timescales of shock processes in chondritic and martian meteorites. P. Beck, Ph. Gillet, A. El Goresy and S. Mostefaoui. NATURE, Vol. 435 , 23 June 2005

60Fe: a heat source for planetary differentiation from a nearby supernovae explosion. Smail Mostefaoui, G.W. Lugmair and P. Hoppe. The Astrophysical Journal, 625:271-277, 2005 May 20

Supernova graphite in the NanoSIMS: Carbon, oxygen and titanium isotopic compositions of a spherule and its TiC sub-components. F.J.Stadermann, T.K.Croat, T.J.Bernatowicz, S.Amari, S.Messenger, R.M.Walker and E.Zinner. Geochimica and Cosmochimica Acta, Vol.69, No.1, 2005

Discovery of ancient silicate stardust in a meteorite. Ann N. Nguyen and Ernst Zinner. SCIENCE, Vol.303 , 5 March 2004, p.1496-1499

Carbon and nitrogen isotopic anomalies in an anhydrous interplanetary dust particle. Christine Floss, Frank J.Stadermann, John Bradley, Zu Rong Dai, Sasa Bajt, Giles Graham. SCIENCE, Vol 303, 27 February 2004, p.1355 -1358

Polytype Distribution in Circumstellar Silicon Carbide.
T. L. Daulton, T. J. Bernatowicz, R. S. Lewis, S. Messenger, F. J. Stadermann, and S. Amari . Science 7 June 2002: 1852-1855.
> Download pdf (0.3 MB)

Samples of stars beyond the solar system: silicates grains in Interplanetary dust. Scott Messenger, Lindsay P. Keller, Frank J. Stadermann, Robert M. Walker, Ernst Zinner. SCIENCE, Vol. 300, Issue 5616, 105-108, April 4, 2003

A NanoSIMS study of Si- and Ca-Ti-isotopic compositions of presolar silicon carbide grains from supernovae. Astrid Besmehn and Peter Hoppe. Geochemica et Cosmochemica Acta, Vol. 67, No 24, pp. 4693-4703, 2003  

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Quasi-simultaneous acquisition of nine secondary ions with seven detectors on NanoSIMS50L: application to biological samples. Christelle Guillermier, Matthew L. Steinhauser, and Claude P. Lechene. Surf. Interface Anal. (2014), DOI 10.1002/sia.5496
> Download pdf (2.14 MB)

Correlated optical and isotopic nanoscopy. Sinem K. Saka, Angela Vogts, Katharina Kröhnert, François Hillion, Silvio O. Rizzoli & Johannes T. Wessels. Nature Communications. 2014 April. DOI:10.1038/ncomms4664
> Download pdf (1.46 MB)

Simultaneous Hydrogen and Heavier Element Isotopic Ratio Images with a Scanning Submicron Ion Probe and Mass Resolved Polyatomic Ions. Slodzian G, Wu TD, Bardin N, Duprat J, Engrand C, Guerquin-Kern JL. Microsc Microanal. 2014 Feb 19:1-5

Development and characterization of the new NanoSIMS 50L.
F.Hillion, F.Horreard, M.Schuhmacher. Poster for SIMS XVI, Kanazawa, Japan, Oct. 2007
> Download (1.2 MB)

QSA influences on isotopic ratio measurements. G.Slodzian, F. Hillion, F. J. Stadermann, E. Zinner. The Applied Surface Science 231–232 (2004) 874–877, May 2004
> Download pdf (90 KB)

Precise in situ measurements of isotopic abundances with pulse counting of sputtered ions. G.Slodzian, M. Chaintreau, R. Dennebouy, A. Rousse. The European physical journal applied physics, March 2001
> Download pdf (3.23 MB)

Recent results and developments on the CAMECA NanoSIMS 50.
F.Hillion, F.Horreard, F.J.Stadermann. Poster for SIMS XII, Brussels, Belgium, Sep. 1999

The CAMECA NanoSIMS 50: Experimental results. F.Hillion, B.Daigne, F.Girard, G.Slodzian. Proceedings of SIMS X, p.979, Münster, Germany, 1995

A new high performance instrument: the CAMECA NanoSIMS 50. F.Hillion, B.Daigne, F.Girard, G.Slodzian, Proceedings of SIMS IX, p.254, Yokohama, Japan, 1993

Ion optics for a high resolution scanning ion microscope and spectrometer : transmission evaluations. G.Slodzian, B.Daigne, F.Girard, F.Hillion, Proceedings of SIMS IX, p.294, Yokohama, Japan, 1993

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Pharmacology & Cosmetics


Multi-scale imaging of anticancer platinum(IV) compounds in murine tumor and kidney. A. A. Legin, S. Theiner, A. Schintlmeister, S. Reipert, P. Heffeter, M. A. Jakupec, J. Mayr, H. P. Varbanov, C. R. Kowol, M. Galanski, W. Berger, M. Wagner and B. K. Keppler.  Chemical Science, 3 feb 2016. DOI: 10.1039/c5sc04383b
> Download pdf (1.4 MB)

NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound. Louise E. Wedlock, Matt R. Kilburn, Rong Liu, Jeremy A. Shaw, Susn J. Berners-Price and Nicholas P. Farrell. Chem. Commun., 2013,49, 6944-6946
> Download pdf (1.7 MB)

Visualising gold inside tumour cells following treatment with an antitumour gold(I) complex. Louise E. Wedlock, Matt R. Kilburn, John B. Cliff, Luis Filgueira, Martin Saunders and Susn J. Berners-Price. Metallomics, 2011,3, 917-925
> Download pdf (4.6 MB)

NanoSIMS analysis of an isotopically labelled organometallic ruthenium(ii) drug to probe its distribution and state in vitro. Lee RF, Escrig S, Croisier M, Clerc-Rosset S, Knott GW, Meibom A, Davey CA, Johnsson K, Dyson PJ. Chem Commun (Camb). 2015 Oct 1. DOI 10.1039/c5cc06983a
> Download pdf (7.3 MB)

Multiplexed ion beam imaging of human breast tumors.
Michael Angelo, Sean C Bendall, Rachel Finck, Matthew B Hale, Chuck Hitzman, Alexander D Borowsky, Richard M Levenson, John B Lowe, Scot D Liu, Shuchun Zhao, Yasodha Natkunam & Garry P Nolan. Nature medicine. 2 March 2014. DOI:10.1038/nm.3488
> Download pdf (4.10 MB)

NanoSIMS combined with fluorescence microscopy as a tool for subcellular imaging of isotopically labeled platinum-based anticancer drugs. Anton A. Legin, Arno Schintlmeister, Michael A. Jakupec, Markus Galanski, Irene Lichtscheidl, Michael Wagnercd and Bernhard K. Keppler. Chemical Science, 2014, 5, 3135. DOI: 10.1039/c3sc53426j
> Download pdf (4.25 MB)

Copper and calcium uptake in colored hair. K.E. Smart, M. Kilburn, M. Schrieder, B.G.H. Martin, C. Hawes, J.M. Marsh, C.R.M. Grovenor, J. Cosmet. Sci., 60, 337–345 (May/June 2009) 337
> Download pdf (2.22 MB)

Investigation of the cosmetic ingredient distribution in the stratum corneum using NanoSIMS imaging. N. Tanji, M. Okamoto, Y. Katayama, M. Hosokawa, N. Takahata, Y. Sano. Applied Surface Science 255 (2008) 1116–1118. doi:10.1016/j.apsusc.2008.05.187
> Download pdf (0.47 MB)

In-situ imaging mass spectrometry analysis of melanin granules in the human hair shaft. P. Hallegot, P. Peteranderl, R. Lechene, C., J Invest Dermatol 2004, 122, (2), 381-6
> Download pdf (3.38 MB)

Ultra-structural cell distribution of the melanoma marker iodobenzamide: improved potentiality of SIMS imaging in life sciences. Jean-Luc Guerquin-Kern, François Hillion, Jean-Claude Madelmont, Pierre Labarre, Janine Papon & Alain Croisy.
> Download pdf (880 KB)


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Paleobiology / Evolution

Sulfur isotopes of organic matter preserved in 3.45-billion-year-old stromatolites reveal microbial metabolism. Tomaso R. R. Bontognali, Alex L. Sessions, Abigail C. Allwood, Woodward W. Fischer, John P. Grotzinger, Roger E. Summons and John M. Eiler. PNAS September 18, 2012 vol. 109 no. 38
> Download pdf (3.3 MB)

The ancient evolutionary origins of Scleractinia revealed by azooxanthellate corals. Jarosław Stolarski, Marcelo V Kitahara, David J Miller, Stephen D Cairns, Maciej Mazur and Anders Meibom. BMC Evolutionary Biology 2011, 11:316
> Download pdf (4.85 MB)

A Cretaceous Scleractinian Coral with a Calcitic Skeleton. Jaroslaw Stolarski, et al. Science 318, 92 (2007); DOI: 10.1126/science.1149237
> Download pdf (3.03 MB)

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