NanoSIMS 50: Ion microprobe with multicollection of up to seven masses and 50nm lateral resolution. Among the applications:
- simultaneous single cell phylogenic identification and metabolic activity measurement in environmental microbiology.
- protein renewal at cellular or intra-cellular level in medical field,

- localization of molecules labeled with rare elements or isotopes at cellular or intra-cellular level in pharmacology.
Most of these applications are based on the images of the distribution and measurement of the accumulation of several molecules labeled with different stable isotopes (e.g. 15N, 13C, 2H, 18O, 33S, 74Se, ...). Multiple labeling can be used on different or on the same molecules.
Multiple Isotope Imaging Mass Spectrometry (MIMS) offers a novel, powerful and quantitative technique for studying intra- and trans-cellular metabolic pathways, signal transduction, cytoplasmic and nucleo-cytoplasmic translocations, RNA and DNA expression and distribution, vesicular and non-vesicular trafficking, virus penetration, and localization of drugs.